Recent progress of aggregation-induced emission luminogens (AIEgens) for bacterial detection and theranostics,Materials Chemistry Frontiers

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Recent progress of aggregation-induced emission luminogens (AIEgens) for bacterial detection and theranostics
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2020-10-30 , DOI: 10.1039/d0qm00753f
Xuping Feng _{1,

2,

3} , Bin Tong _{1,

2,

3} , Jianbing Shi _{1,

2,

3} , Changsheng Zhao _{3,

4,

5} , Zhengxu Cai _{1,

2,

3} , Yuping Dong _{1,

2,

3}

Affiliation

Bacterial infections have become one of the greatest threats to human health. The emergence of drug-resistant bacteria poses an urgent need to avoid bacterial resistance and sterilize bacteria. The fluorescence technology for the detection and image-guided therapy has attracted considerable attention. However, traditional fluorescent dyes suffering from aggregation-caused quenching are not suitable for biomedical applications. Aggregation-induced emission luminogens (AIEgens) that display strong emission in aggregated states, low background, high signal-to-noise ratio and sensitivity, and high resistance to photobleaching, may circumvent this problem. On the other hand, the overuse of anti-bacterial antibiotics diminishes their effect. It is imperative to develop novel antimicrobial approaches that could effectively avoid bacterial resistance. The development of AIEgens for bacterial detection and theranostics has recently caused a lot of concern, which is ascribed to their remarkable advantage compared with traditional organic fluorescent probes. The application of AIEgens in bacterial detection and treatment in the past five years was reviewed in this paper, including advancements in the development of versatile AIEgens for bacteria imaging, detection, and potential clinic therapy.

中文翻译：

聚集诱导的发光致发光剂（AIEgens）在细菌检测和治疗中的最新进展

细菌感染已成为对人类健康的最大威胁之一。耐药细菌的出现迫切需要避免细菌耐药和对细菌进行灭菌。用于检测和图像引导疗法的荧光技术引起了极大的关注。然而，遭受聚集引起的猝灭的传统荧光染料不适合生物医学应用。在聚集状态下显示强发射，低背景，高信噪比和灵敏度以及高抗光漂白性的聚集诱导发射发光剂（AIEgens）可以解决此问题。另一方面，过度使用抗菌抗生素会降低其作用。必须开发能够有效避免细菌耐药性的新型抗菌方法。最近，用于细菌检测和诊断学的AIEgens的发展引起了很多关注，这归因于它们与传统有机荧光探针相比的显着优势。本文对AIEgens在过去五年中在细菌检测和治疗中的应用进行了综述，包括在细菌成像，检测和潜在临床治疗中开发通用AIEgens的进展。

更新日期：2020-12-10

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