Krebs von den Lungen (KL-6) is elevated in serum of interstitial lung disease (ILD) patients based on its leakage from the alveolar space into the blood; KL-6 is significantly higher in patients with acute exacerbation of ILDs (AE-ILD) compared with stable patients. This study aimed to determine the sensitivity and specificity of KL6 to detect AE-ILD. This is a prospective cross sectional observational study was carried out on 88 subjects at the Chest Department, Minia Cardiothoracic University Hospital, during the period from August 2018 to August 2019. This study was approved by the hospital research ethics board of Minia University and informed consent was obtained. History, examination, spirometry, ABGs, X-ray, HRCT, CBC, ESR, CRP, and KL6 levels were done to both stable and exacerbation groups of ILDs. The level of biomarkers is compared between both groups and control. Statistical analysis done by using IBM SPSS statistical package version 20 (χ2 test and independent sample t test, ANOVA test, bivariate Pearson correlation analysis, and ROC curve analysis). The study showed that there is a significant difference between stable and exacerbating groups regarding fever, signs of RHF, dyspnea scale, FVC, and PaO2. KL-6 cutoff ≥ 187.5 U/ml could exhibit AE-ILDs with a sensitivity of 98% and a specificity of 97%. KL-6 is a more sensitive and specific marker to detect AE-ILD.

中文翻译：

---

血清Krebs von den Lungen（KL-6）水平是间质性肺疾病恶化的标志

间质性肺病（ILD）患者的血清中Krebs von den Lungen（KL-6）从肺泡腔渗入血液而升高；与稳定患者相比，患有ILD急性加重（AE-ILD）的患者KL-6明显更高。这项研究旨在确定KL6检测AE-ILD的敏感性和特异性。这是一项前瞻性横断面观察研究，于2018年8月至2019年8月期间在Minia心胸大学医院胸科对88位受试者进行了研究。该研究获得Minia大学医院研究伦理委员会的批准并获得知情同意获得了。对ILD的稳定组和恶化组进行了病史，检查，肺活量测定，ABG，X射线，HRCT，CBC，ESR，CRP和KL6水平。在两组和对照组之间比较生物标志物的水平。使用IBM SPSS统计软件包第20版进行统计分析（χ2检验和独立样本t检验，ANOVA检验，双变量Pearson相关分析和ROC曲线分析）。研究表明，稳定组和恶化组之间在发烧，RHF征兆，呼吸困难量表，FVC和PaO2方面存在显着差异。KL-6截留值≥187.5 U / ml时可显示AE-ILD，其敏感性为98％，特异性为97％。KL-6是检测AE-ILD的更敏感，更特异性的标记。研究表明，稳定组和恶化组之间在发烧，RHF征兆，呼吸困难量表，FVC和PaO2方面存在显着差异。KL-6截留值≥187.5 U / ml时可表现出AE-ILD，其敏感性为98％，特异性为97％。KL-6是检测AE-ILD的更敏感，更特异性的标记。研究表明，稳定组和恶化组之间在发烧，RHF征兆，呼吸困难量表，FVC和PaO2方面存在显着差异。KL-6截留值≥187.5 U / ml时可表现出AE-ILD，其敏感性为98％，特异性为97％。KL-6是检测AE-ILD的更敏感，更特异性的标记。