There is increasing evidence demonstrating that adult neural stem cells (NSCs) are a cell of origin of glioblastoma. Here we analyzed the interaction between transformed and wild-type NSCs isolated from the adult mouse subventricular zone niche. We found that transformed NSCs are refractory to quiescence-inducing signals. Unexpectedly, we also demonstrated that these cells induce quiescence in surrounding wild-type NSCs in a cell–cell contact and Notch signaling-dependent manner. Our findings therefore suggest that oncogenic mutations are propagated in the stem cell niche not just through cell-intrinsic advantages, but also by outcompeting neighboring stem cells through repression of their proliferation.

中文翻译：

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胶质母细胞瘤干细胞通过 Notch 信号传导诱导周围神经干细胞静止


越来越多的证据表明成体神经干细胞（NSC）是胶质母细胞瘤的起源细胞。在这里，我们分析了从成年小鼠室下区微环境分离的转化型和野生型 NSC 之间的相互作用。我们发现转化的 NSC 对静止诱导信号具有抵抗力。出乎意料的是，我们还证明这些细胞以细胞间接触和 Notch 信号依赖的方式诱导周围野生型 NSC 的静止。因此，我们的研究结果表明，致癌突变在干细胞生态位中传播不仅是通过细胞固有的优势，而且还通过抑制邻近干细胞的增殖来竞争。