Pyrazolo-oxazine fused systems are interesting classes of heterocyclic compounds exhibiting pronounced biological applications such as anticancer, antitubercular, anti-inflammatory, antibacterial and antifungal activities as well as inhibiting COX-1 and COX-2 enzymes. Depending on the distribution position of the heteroatoms (N and O), there are fourteen different systems of pyrazolo-oxazine. Nine of them were biologically abundant in literature, for example, pyrazolo[3,4-e][1,3]oxazines are used as analogs of antibiotics Formycin, Formycin B, Oxoformycin B. This review article summarizes the concerted efforts expended on most of the synthetic routes to the various types of pyrazolo-oxazines in the literature until the first quarter of 2020. The reactions of pyrazolo-oxazines with various reagents are also outlined.

吡唑并恶嗪稠合系统是有趣的杂环化合物类，具有明显的生物学应用，例如抗癌，抗结核，抗炎，抗菌和抗真菌活性以及抑制COX-1和COX-2酶。根据杂原子（N和O）的分布位置，有十四种吡唑并恶嗪系统。其中有九种在生物学上有丰富的文献，例如吡唑并[3,4-e] [1,3]恶嗪被用作抗生素福霉素，福霉素B，氧福霉素B的类似物。到2020年第一季度为止，各种类型的吡唑并恶嗪的合成途径的概述。也概述了吡唑并恶嗪与各种试剂的反应。