Long-acting injectable antiretroviral therapy (LAI-ART) is one of the latest advancements in HIV control with the potential to overcome oral ART barriers to adherence. The objective of this article is to anticipate and examine implementation considerations for LAI-ART using components of the PRISM model, a Practical, Robust Implementation and Sustainability Model for integrating research findings into practice. We conducted a scoping review from January to August 2020 of the growing literature on LAI-ART implementation and other fields using LAI therapies. Key considerations regarding LAI-ART were parsed from the searches and entered into the PRISM implementation science framework. The PRISM framework posed multiple questions for consideration in the development of an optimal implementation strategy for LAI-ART in the United States. These questions revealed the necessity for more data, including acceptability of LAI-ART among many different subgroups of people living with HIV (PLWH), cost effectiveness, patient satisfaction, and patient-reported outcomes, as well as more detailed information related to the external environment for optimal LAI-ART implementation. Ethical considerations of LAI-ART will also need to be considered. The anticipation of, and excitement for, LAI-ART represent the hope for a new direction for HIV treatment that reduces adherence barriers and improves prognoses for PLWH. We have a unique window of opportunity to anticipate implementation considerations for LAI-ART, so this new therapy can be used to its fullest potential. Outstanding questions remain, however, that need to be addressed to help achieve HIV suppression goals in diverse populations.

中文翻译：

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LAI 来了！美国长效注射抗逆转录病毒疗法实施的科学考虑：范围界定审查


长效注射抗逆转录病毒疗法 (LAI-ART) 是艾滋病毒控制领域的最新进展之一，有可能克服口服 ART 的依从性障碍。本文的目的是使用 PRISM 模型的组件来预测和检查 LAI-ART 的实施注意事项，PRISM 模型是一个实用、稳健的实施和可持续性模型，用于将研究成果融入实践。我们从 2020 年 1 月至 8 月对越来越多的有关 LAI-ART 实施和使用 LAI 疗法的其他领域的文献进行了范围界定审查。从搜索中解析出有关 LAI-ART 的关键考虑因素，并将其输入到 PRISM 实施科学框架中。 PRISM 框架提出了在美国制定 LAI-ART 最佳实施策略时需要考虑的多个问题。这些问题揭示了需要更多数据的必要性，包括 LAI-ART 在艾滋病毒感染者 (PLWH) 的许多不同亚组中的可接受性、成本效益、患者满意度和患者报告的结果，以及与外部相关的更详细信息。最佳 LAI-ART 实施的环境。 LAI-ART 的伦理考虑也需要考虑。对 LAI-ART 的期待和兴奋代表了对 HIV 治疗新方向的希望，该治疗可以减少依从性障碍并改善 PLWH 的预后。我们有一个独特的机会来预测 LAI-ART 的实施考虑因素，因此这种新疗法可以充分发挥其潜力。然而，仍然存在一些悬而未决的问题，需要解决这些问题，以帮助在不同人群中实现艾滋病毒抑制目标。