Cell adhesion molecules (CAMs) mediate interactions of neurons with the extracellular environment by forming adhesive bonds with CAMs on adjacent membranes or via binding to proteins of the extracellular matrix. Binding of CAMs to their extracellular ligands results in the activation of intracellular signaling cascades, leading to changes in neuronal structure and the molecular composition and function of neuronal contacts. Ultimately, many of these changes depend on the synthesis of new proteins. In this review, we summarize the evidence showing that CAMs regulate protein synthesis by modulating the activity of transcription factors, gene expression, protein translation, and the structure and distribution of organelles involved in protein synthesis and transport.

细胞粘附分子（CAMs）通过与CAMs在相邻膜上或细胞表面形成粘附键来介导神经元与细胞外环境的相互作用。 通过与细胞外基质蛋白结合。CAM与其细胞外配体的结合导致细胞内信号传导级联的激活，导致神经元结构以及神经元接触的分子组成和功能的改变。最终，许多这些变化取决于新蛋白质的合成。在这篇综述中，我们总结了证据表明CAM通过调节转录因子的活性，基因表达，蛋白质翻译以及参与蛋白质合成和运输的细胞器的结构和分布来调节蛋白质合成。