Background: Unlike what obtains in childhood-onset type 1 diabetes, there remains a paucity of data on adult-onset type 1 diabetes in Nigeria. Hence, the current study aimed to determine the general characteristics of adult-onset type 1 diabetes among subjects (aged ≥18 years) presenting at the University of Uyo Teaching Hospital (UUTH) in Akwa Ibom State, South-south Nigeria. Methods: A 5-year (2014–2018) retrospective records review of subjects with type 1 diabetes was undertaken, using hospital medical records retrieved from the Department of Health Information Management of UUTH. Diagnosed adult cases of type 1 diabetes were meticulously identified and the relevant data at the point of initial diagnosis were acquired on a specially designed data acquisition template. Results: A total of 47,357 medical cases were identified of which 362 adults were diagnosed with type I diabetes (mean age 33.12 ± 4.40, range 20–51 years) and the females (n = 204; 56.4%) predominated among those diagnosed. The overall, male gender, and female gender prevalence was 7.4/1,000 (95% confidence interval [CI]: 6.89–7.98), 3.3/1,000 (95% CI: 2.52–4.08), and 4.3/1,000 (95% CI: 3.61–4.99), respectively. The females exhibited the highest trough, peak, annual, and overall prevalence during the study period. The female gender (OR: 2.334; 95% CI: 1.407–3.478; p = 0.010), age ≤30 years (OR: 1.976; 95% CI: 0.875–3.211; p #x3c; 0.001), urban-dwelling (OR: 3.243; 95% CI: 2.3407.780; #x3c;0.001), diabetes family history (OR: 1.365; 95% CI: 0.678–2.010; p = 0.033), and the rainy season (OR: 1.129; 95% CI: 0.401–1.910; p #x3c; 0.001) were independent predictors among the overall adult type 1 diabetics. On gender-segregated analyses, age ≤30 years, urban-dwelling, diabetes family history, and the rainy season remained independent predictors among the male and female adult type 1 diabetics (p #x3c; 0.05). Conclusion: The study demonstrated a high burden of type 1 diabetes among adult residents of Uyo, Akwa Ibom State, South-South Nigeria. The predictors of adult type 1 diabetes, identified in the present study, are valuable epidemiologic evidence for the design of type 1 diabetes-targeted preventive programs by various concerned stakeholders.
Dubai Diabetes Endocrinol J

中文翻译：

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尼日利亚乌约的成人1型糖尿病的类型，趋势和预测因素

背景：与在儿童期1型糖尿病中获得的数据不同，在尼日利亚，关于成人1型糖尿病的数据仍然很少。因此，本研究旨在确定在尼日利亚南南阿克瓦伊博姆州乌约大学教学医院（UUTH）的大学（≥18岁）受试者中成人1型糖尿病的一般特征。方法：使用从UUTH的健康信息管理部门获得的医院病历，对1型糖尿病受试者进行了为期5年（2014-2018年）的回顾性记录回顾。精心识别已诊断的成人1型糖尿病病例，并在特别设计的数据采集模板上采集初次诊断时的相关数据。结果：总共鉴定出47,357例医疗病例，其中362名被诊断为I型糖尿病的成年人（平均年龄33.12±4.40，范围为20-51岁），而女性（n = 204； 56.4％）居首位。总体，男性和女性患病率分别为7.4 / 1,000（95％置信区间[CI]：6.89–7.98），3.3 / 1,000（95％CI：2.52–4.08）和4.3 / 1,000（95％CI： 3.61–4.99）。在研究期间，雌性的谷值，高峰，年度和总体患病率最高。女性，市区居民（OR ：2.334; 95％CI：1.407–3.478; p = 0.010），年龄≤30岁（OR：1.976; 95％CI：0.875–3.211; p＃x3c; 0.001） ：3.243; 95％CI：2.3407.780;＃x3c; 0.001），糖尿病家族史（OR：1.365; 95％CI：0.678-2.010;p = 0.033）和雨季（OR：1.129； 95％CI：0.401–1.910；p＃x3c； 0.001）是整个成年1型糖尿病患者的独立预测因子。在按性别分类的分析中，年龄≤30岁，城市居民，糖尿病家族史和雨季仍然是成年1型男性和女性糖尿病患者的独立预测因子（p＃x3c； 0.05）。结论：该研究表明尼日利亚南部和南部阿克瓦伊博姆州乌约市成年居民的1型糖尿病负担很高。在本研究中确定的成人1型糖尿病的预测因素，是有关各方设计1型糖尿病为目标的预防计划的有价值的流行病学证据。
迪拜糖尿病内分泌J