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4‐1BB costimulation promotes bystander activation of human CD8 T cells
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-11-12 , DOI: 10.1002/eji.202048762
Manuel Reithofer 1 , Sandra Rosskopf 2 , Judith Leitner 2 , Claire Battin 2 , Barbara Bohle 1 , Peter Steinberger 2 , Beatrice Jahn-Schmid 1
Affiliation  

Costimulatory signals potently promote T‐cell proliferation and effector function. Agonistic antibodies targeting costimulatory receptors of the TNFR family, such as 4‐1BB and CD27, have entered clinical trials in cancer patients. Currently there is limited information how costimulatory signals regulate antigen‐specific but also bystander activation of human CD8 T cells.

中文翻译:

4-1BB 共刺激促进人类 CD8 T 细胞的旁观者激活

共刺激信号有效促进 T 细胞增殖和效应子功能。针对 TNFR 家族共刺激受体(如 4-1BB 和 CD27)的激动性抗体已进入癌症患者的临床试验。目前,关于共刺激信号如何调节人类 CD8 T 细胞的抗原特异性以及旁观者激活的信息有限。
更新日期:2020-11-12
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