The purpose of this study was to investigate the effects of moderate‐intensity static magnetic field (SMF) on diabetic mice. We studied the effects of SMF on blood glucose of normal mice by starch tolerance and glucose tolerance tests. Then, we evaluated the effects of SMF on blood glucose of diabetic mice by establishing alloxan‐induced type 1 diabetic mice and high‐fat diet + streptozotocin (STZ)‐induced type 2 diabetic mice. The results showed that different magnetic field intensities and blank control did not affect the blood glucose of normal mice. After starch and glucose administration, different magnetic fields could improve the glucose tolerance of normal mice, and this was obvious in the 600 mT group. In the experiment of type 1 diabetic mice induced by alloxan, the results showed that different magnetic field intensities could improve the starch tolerance of mice, and that in the 400 mT group was obvious. In the experiment of type 2 diabetic mice induced by a high‐fat diet + STZ, the 400 mT group could reduce food intake and water consumption in the later period. The 600 mT group could improve the starch tolerance of mice. The 400 and 600 mT groups could reduce fasting blood glucose. At the same time, total cholesterol and triglyceride decreased in different magnetic field intensities, and the 600 mT group could significantly increase the serum insulin content of mice. In summary, the results of this study suggest that SMF has a protective role in diabetic mice. Bioelectromagnetics. © 2020 Bioelectromagnetics Society

中文翻译：

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中等强度静磁场对糖尿病小鼠的保护作用


本研究的目的是研究中等强度静磁场（SMF）对糖尿病小鼠的影响。我们通过淀粉耐量和葡萄糖耐量试验研究了SMF对正常小鼠血糖的影响。然后，我们通过建立四氧嘧啶诱导的1型糖尿病小鼠和高脂饮食+链脲佐菌素（STZ）诱导的2型糖尿病小鼠，评估了SMF对糖尿病小鼠血糖的影响。结果表明，不同磁场强度和空白对照对正常小鼠的血糖没有影响。给予淀粉和葡萄糖后，不同磁场均能改善正常小鼠的糖耐量，且在600 mT组中效果明显。在四氧嘧啶诱导的1型糖尿病小鼠实验中，结果表明，不同磁场强度均能提高小鼠的淀粉耐受性，且在400 mT组中效果明显。在高脂饮食+STZ诱发2型糖尿病小鼠的实验中，400 mT组可以减少后期的摄食量和饮水量。 600 mT组可提高小鼠淀粉耐受性。 400和600 mT组可以降低空腹血糖。同时，不同磁场强度下总胆固醇和甘油三酯均降低，且600 mT组可显着升高小鼠血清胰岛素含量。综上所述，本研究结果表明 SMF 对糖尿病小鼠具有保护作用。生物电磁学。 © 2020 生物电磁学会