Cissus sicyoides L. is a plant that has great anti-inflammatory activity, due to the presence of phenolic compounds. The objective of this work was to identify such substances by HPLC and to evaluate the cytotoxic effect on human red blood cells, of the C. sicyoides extract obtained by supercritical extraction, using CO₂ and EtOH as co-solvent, in comparison to the extract obtained by conventional extraction (Soxhlet), as well as, to evaluate its anti-inflammatory effect on spinal cord injury (SCI) in adult rats. In HPLC analysis, the UV/Visible spectral data revealed compounds with absorption bands in wavelengths characteristic of glycosylated flavonoids. The supercritical extract did not show cytotoxic effect, as there was no rupture of red blood cell membranes. The in vivo test demonstrated reduction in cell concentration in the lesion surrounding area in treated animals, suggesting an anti-inflammatory effect of the supercritical extract on the SCI model.

Ciss sicyoides L.是一种由于存在酚类化合物而具有出色的抗炎活性的植物。这项工作的目的是通过HPLC鉴定此类物质，并评估与提取物相比，超临界提取方法（使用超临界提取法）获得的长毛隐孢子虫提取物对人红细胞的细胞毒性作用，超临界提取法使用的是CO ₂和EtOH作为共溶剂。通过常规提取（索氏提取法）获得的，以及评估其对成年大鼠脊髓损伤（SCI）的抗炎作用。在HPLC分析中，UV /可见光谱数据显示出在糖基化类黄酮的特征波长处具有吸收带的化合物。超临界提取物没有显示出细胞毒性作用，因为没有红细胞膜破裂。的体内试验表明，治疗动物病变周围区域的细胞浓度降低，表明超临界提取物对SCI模型具有抗炎作用。