Adipose tissue is recognized as a fundamental endocrine organ. Nowadays, we are also aware that it contains the highest number of stromal cells (ASCs) per unit of volume. These cells can differentiate between different phenotypes among which the adipocytes. The aim of this work was to verify whether orexin B, crucial mediator of the energy balance, modifies the differentiation of cultured ASCs. We used the pig as a model. Our data demonstrate that swine ASCs express prepro-orexin. Orexin B treatment inhibits ASCs proliferation (P < 0.05) and adipogenic differentiation (P < 0.05). Data collected could be interesting both in animal production field because consumers require lean meat, and in human medicine study about obesity because pig can be considered a valuable animal model for translational studies.

脂肪组织被认为是一种基本的内分泌器官。如今，我们也知道它每单位体积包含最多数量的基质细胞 (ASC)。这些细胞可以区分不同的表型，其中脂肪细胞。这项工作的目的是验证食欲素 B（能量平衡的关键介质）是否会改变培养的 ASC 的分化。我们以猪为模型。我们的数据表明猪 ASCs 表达 prepro-orexin。Orexin B 处理抑制 ASCs 增殖 ( P < 0.05) 和成脂分化 ( P< 0.05)。收集的数据在动物生产领域可能很有趣，因为消费者需要瘦肉，而在关于肥胖的人类医学研究中，猪可以被认为是转化研究的有价值的动物模型。