It is well known that iron oxide magnetic nanoparticles (IONPs) have many potential utilities in biomedicine due to their unique physicochemical properties. With the aim to obtain multifunctional nanoparticles with potential uses for therapy and diagnosis (nanotheranostics), IONPs were synthesized by hydrothermal synthesis assisted by mannose. Two synthetic pathways were evaluated in order to obtain IONPs with suitable properties for biomedical applications. The formulation Mag@Man/H1 presented the best characteristics in terms of size and stability. Mag@Man/H1 was evaluated as: a) drug carrier, b) antioxidant activity, c) magnetic hyperthermia, d) contrast agent for MRI. To evaluate the point a), morin, a natural flavonoid with several pharmaceutical activities, was loaded on the nanoparticles. A high percentage of drug loading was achieved. In point b) it was determined that the carrier itself possess a high activity which increased in morin loaded nanoparticles. Point c) magnetocalorimetric evaluation were carried out at several field conditions. A specific absorption rate value of 121.4 W/gFe was achieved at 52.4 kA/m and 260 kHz and 8.8 W/gFe at 4 kA/m and 100 kHz. Regarding contrast capacity (point d), the r1 value found was close to some contrast agent based on manganese. Although the measured r2 value was quite smaller than other iron oxides, the achieved effect was strong enough to produce negative contrast. From these studies, it was concluded that Mag@Man/H1 could act as a multifunctional nanoplatform for oncological diseases treatments.

众所周知，氧化铁磁性纳米粒子（IONPs）由于其独特的物理化学性质，在生物医学中具有许多潜在的实用性。为了获得在治疗和诊断方面具有潜在用途的多功能纳米粒子（纳米化学），在甘露糖的辅助下通过水热合成法合成了IONP。为了获得具有适合生物医学应用性质的IONP，对两种合成途径进行了评估。Mag @ Man / H1配方在尺寸和稳定性方面表现出最佳特性。Mag @ Man / H1被评估为：a）药物载体，b）抗氧化活性，c）磁热疗，d）MRI造影剂。为了评估点a），将具有几种药物活性的天然类黄酮莫林负载在纳米颗粒上。实现了较高的载药量百分比。在点b）中，确定了载体本身具有高活性，该活性在装载有蛋白粉的纳米颗粒中增加。c）点磁量热法评估是在几个现场条件下进行的。在52.4 kA / m和260 kHz时达到121.4 W / gFe的比吸收率值，在4 kA / m和100 kHz时达到8.8 W / gFe。关于对比能力（点d），发现的r1值接近于某些基于锰的对比剂。尽管测得的r2值比其他氧化铁小得多，但获得的效果足以产生负对比度。从这些研究中可以得出结论，Mag @ Man / H1可以充当用于肿瘤疾病治疗的多功能纳米平台。c）点磁量热法评估是在几个现场条件下进行的。在52.4 kA / m和260 kHz时达到121.4 W / gFe的比吸收率值，在4 kA / m和100 kHz时达到8.8 W / gFe。关于对比能力（点d），发现的r1值接近于某些基于锰的对比剂。尽管测得的r2值比其他氧化铁小得多，但获得的效果足以产生负对比度。从这些研究中可以得出结论，Mag @ Man / H1可以充当用于肿瘤疾病治疗的多功能纳米平台。c）点磁量热法评估是在几个现场条件下进行的。在52.4 kA / m和260 kHz时达到121.4 W / gFe的比吸收率值，在4 kA / m和100 kHz时达到8.8 W / gFe。关于造影剂容量（d点），发现的r1值接近某些基于锰的造影剂。尽管测得的r2值比其他氧化铁小得多，但获得的效果足以产生负对比度。从这些研究中可以得出结论，Mag @ Man / H1可以充当用于肿瘤疾病治疗的多功能纳米平台。r1值接近于一些基于锰的造影剂。尽管测得的r2值比其他氧化铁小得多，但获得的效果足以产生负对比度。从这些研究中可以得出结论，Mag @ Man / H1可以充当用于肿瘤疾病治疗的多功能纳米平台。r1值接近于一些基于锰的造影剂。尽管测得的r2值比其他氧化铁小得多，但获得的效果足以产生负对比度。从这些研究中可以得出结论，Mag @ Man / H1可以充当用于肿瘤疾病治疗的多功能纳米平台。