Molecular Diversity ( IF 3.9 ) Pub Date : 2020-11-12 , DOI: 10.1007/s11030-020-10149-4 Ayushi Sethiya 1 , Nusrat Sahiba 1 , Pankaj Teli 1 , Jay Soni 1 , Shikha Agarwal 1
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Abstract
Benzothiazole is a privileged scaffold in the field of synthetic and medicinal chemistry. Its derivatives and metal complexes possess a gamut of pharmacological properties and high degree of structural diversity that has proven it vital for the investigation for novel therapeutics. The 2nd position of benzothiazole is the most active site that makes 2-arylbenzothiazole as felicitous scaffolds in pharmaceutical chemistry. The extensive significance of benzo-fused heterocyclic moieties formation has led to broad and valuable different approaches for their synthesis. This review deals with the synthetic approaches developed so far for the synthesis of 2-arylbenzothiazoles. Moreover, this article abridges the publications devoted to the synthesis of this moiety over the last 6 years. This study gives a current precis of research on the fabrication of 2-arylbenzothiazoles through different synthetic pathways and shall be helpful for researchers and scientists who are working in this field to make more potent biologically active benzothiazole-based drugs.
Graphic abstract
中文翻译：
2-芳基苯并噻唑合成策略的最新进展
摘要
苯并噻唑是合成和药物化学领域的一种特殊支架。它的衍生物和金属配合物具有广泛的药理特性和高度的结构多样性，这已证明它对于新疗法的研究至关重要。苯并噻唑的第 2 位是使 2-芳基苯并噻唑成为药物化学中最有效的支架的最活跃的位点。苯并稠合杂环部分形成的广泛意义导致了广泛而有价值的不同合成方法。这篇综述讨论了迄今为止为合成 2-芳基苯并噻唑而开发的合成方法。此外，本文删减了过去 6 年来致力于合成该部分的出版物。
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