The term interchromosomal effect was originally used to describe a change in the distribution of exchange in the presence of an inversion. First characterized in the 1920s by early Drosophila researchers, it has been observed in multiple organisms. Nearly half a century later, the term began to appear in the human genetics literature to describe the hypothesis that parental chromosome differences, such as translocations or inversions, may increase the frequency of meiotic chromosome nondisjunction. Although it remains unclear if chromosome aberrations truly affect the segregation of structurally normal chromosomes in humans, the use of the term interchromosomal effect in this context persists. This article explores the history of the use of the term interchromosomal effect and discusses how chromosomes with structural aberrations are segregated during meiosis.

中文翻译：

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染色体间效应：对不同生物体有不同的含义。


术语“染色体间效应”最初用于描述存在倒位时交换分布的变化。早期果蝇研究人员于 20 年代首次对其进行了表征，现已在多种生物体中观察到该现象。近半个世纪后，该术语开始出现在人类遗传学文献中，用于描述亲本染色体差异（例如易位或倒位）可能会增加减数分裂染色体不分离频率的假设。尽管尚不清楚染色体畸变是否真正影响人类结构正常染色体的分离，但在这种情况下仍然使用术语“染色体间效应”。本文探讨了术语“染色体间效应”的使用历史，并讨论了具有结构畸变的染色体在减数分裂过程中如何分离。