Anaplastic thyroid carcinoma is an uncommon carcinoma representing 1 to 4 % of all thyroid cancers. The carcinoma is most common in females of the eight decades. It is a locally advanced cancer with frequent infiltration of surrounding organs, blood vessels and skin of neck. Paraneoplastic manifestations could occur. Approximately half of the patients with anaplastic thyroid carcinoma had distant metastasis with lung and brain as the most frequent sites of metastasis. The median survival of patients with anaplastic thyroid carcinoma reported was from 1 to 6 months. The current terminology of the cancer in World Health Organization is "anaplastic thyroid carcinoma" rather than "undifferentiated thyroid carcinoma". In the latest American Joint Committee on Cancer (AJCC) TNM staging system for anaplastic thyroid carcinoma, there are updates on T and N categories. To conclude, updated knowledge of clinicopathological features, classification, pathological staging will improve our understanding of the cancer and will help in the management of the patients with this aggressive cancer.

中文翻译：

---

甲状腺未分化癌：WHO 分类、临床病理特征和分期的更新。

甲状腺未分化癌是一种罕见的癌症，占所有甲状腺癌的 1% 至 4%。癌症在八十年代的女性中最为常见。它是一种局部晚期癌症，经常浸润周围器官、血管和颈部皮肤。可能会出现副肿瘤表现。大约一半的甲状腺未分化癌患者有远处转移，肺和脑是最常见的转移部位。据报道，甲状腺未分化癌患者的中位生存期为 1 至 6 个月。世界卫生组织目前对癌症的术语是“未分化甲状腺癌”而不是“未分化甲状腺癌”。在最新的美国癌症联合委员会 (AJCC) 甲状腺未分化癌 TNM 分期系统中，T 和 N 类别有更新。总而言之，临床病理特征、分类、病理分期的最新知识将提高我们对癌症的理解，并将有助于管理患有这种侵袭性癌症的患者。