Symptoms of Parkinson's disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an essential role in the analysis of PD pathophysiology and behavior symptoms. As impairments of hand dexterity function can affect activities of daily living in patients with PD, research on hand dexterity function in NHP models with chronic PD is essential. Traditional rating scales previously used in the evaluation of animal spontaneous behavior were insufficient due to factors related to subjectivity and passivity. Thus, experimentally designed applications for an appropriate apparatus are necessary. In this study, we aimed to longitudinally assess hand dexterity function using hand dexterity task (HDT) in NHP-PD models. To validate this assessment, we analyzed the alteration in Parkinsonian tremor signs and the functionality of presynaptic dopaminergic neuron using positron emission tomography imaging of dopamine transporters in these models. In addition, a significant inverse correlation between HDT and DAT level was identified, but no local bias was found. The correlation with intention tremor signs was lower than the resting tremor. In conclusion, the evaluation of HDT may reflect behavioral symptoms of NHP-PD models. Furthermore, HDT was effectively used to experimentally distinguish intention tremors from other tremors.

中文翻译：

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在患有慢性帕金森氏病的非人类灵长类动物模型中手敏捷功能受损。

由多巴胺能神经元丧失引起的帕金森氏病（PD）症状伴有运动障碍，包括震颤，僵硬，运动迟缓和运动障碍。具有PD的非人类灵长类动物（NHP）模型在PD病理生理和行为症状分析中起着至关重要的作用。由于手灵巧性功能障碍会影响PD患者的日常生活，因此研究具有慢性PD的NHP模型中的手灵巧性功能至关重要。由于与主观性和被动性有关的因素，以前用于评估动物自发行为的传统评分量表不足。因此，有必要针对适当的设备进行实验设计的应用。在这项研究中，我们旨在通过NHP-PD模型中的手部灵活性任务（HDT）纵向评估手部灵活性功能。为了验证该评估，我们在这些模型中使用了多巴胺转运蛋白的正电子发射断层显像，分析了帕金森氏震颤信号的变化和突触前多巴胺能神经元的功能。另外，鉴定出HDT和DAT水平之间显着的负相关，但未发现局部偏倚。与意图性震颤信号的相关性低于静息性震颤。总之，对HDT的评估可能反映了NHP-PD模型的行为症状。此外，HDT被有效地用于通过实验将意图性震颤与其他震颤区分开。HDT和DAT水平之间存在显着的负相关，但未发现局部偏倚。与意图性震颤信号的相关性低于静息性震颤。总之，对HDT的评估可能反映了NHP-PD模型的行为症状。此外，HDT被有效地用于通过实验将意图性震颤与其他震颤区分开。HDT和DAT水平之间存在显着的负相关，但未发现局部偏倚。与意图性震颤信号的相关性低于静息性震颤。总之，对HDT的评估可能反映了NHP-PD模型的行为症状。此外，HDT被有效地用于通过实验将意图性震颤与其他震颤区分开。