Non-coding RNAs are the main component of the extensive transcription results of the mammalian genome. They are not transcribed into proteins but play critical roles in regulating multiple biological processes and affecting cancer progression. m6A modification is one of the most abundant internal RNA modification of mammalian cells, and it involves almost all aspects of RNA metabolism. Recent research revealed tight correlations between m6A modification and ncRNAs and indicated the interaction between m6A and ncRNAs act a pivotal part in the development of cancer. The correlation between m6A modification and ncRNAs provides a new perspective for exploring the potential regulatory mechanism of tumor gene expression, and suggest that m6A modification and ncRNAs may be important prognostic markers and therapeutic targets for multiple cancers. In this review, we summarize the potential regulatory mechanisms between m6A methylation and ncRNAs, highlighting how their relationship affects biological functions in cancer.

中文翻译：

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非编码RNA中的N6-甲基腺嘌呤修饰及其在癌症中的作用

非编码RNA是哺乳动物基因组广泛转录结果的主要组成部分。它们不会被转录成蛋白质，但在调节多种生物过程和影响癌症进展中起着关键作用。m6A修饰是哺乳动物细胞中最丰富的内部RNA修饰之一，它几乎涉及RNA代谢的所有方面。最近的研究揭示了m6A修饰与ncRNA之间的紧密相关性，并表明m6A与ncRNA之间的相互作用是癌症发展中的关键部分。m6A修饰和ncRNA之间的相关性为探索肿瘤基因表达的潜在调控机制提供了新的视角，并表明m6A修饰和ncRNAs可能是多种癌症的重要预后标志物和治疗靶标。