Background The adipose tissues release pro-inflammatory cytokines such as leptin that can be considered a link between obesity and autoimmunity. This study aimed to investigate a possible correlation between BMI, serum leptin, and multiple sclerosis (MS). Methods This case-control study recruited consecutively 169 patients from our MS Unit and 50 healthy controls. Clinical history and examination with Expanded Disability Status Scale (EDSS) scoring were done for all patients. Calculation of body mass index (BMI) and measurement of serum leptin level were done for patients and controls. Results The case group had significantly higher BMI (mean of 26.85 ± 6.06 versus 19.55 ± 1.62; P < 0.001) and higher serum leptin levels (median [IQR] of 280 pgm/ml [175–525] versus 102.5 pgm/ml [80–125]; P < 0.001) compared to the control group. Serum leptin levels did not have a correlation with either disease activity or degree of disability. Conclusions MS patients had significantly higher BMI and higher serum leptin levels compared to controls.

中文翻译：

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埃及多发性硬化症患者样本中的血清瘦素和体重指数

背景 脂肪组织会释放促炎细胞因子，如瘦素，这被认为是肥胖和自身免疫之间的联系。本研究旨在调查 BMI、血清瘦素和多发性硬化症 (MS) 之间可能的相关性。方法 本病例对照研究从我们的 MS 部门连续招募了 169 名患者和 50 名健康对照。对所有患者进行临床病史和扩展残疾状态量表 (EDSS) 评分检查。对患者和对照组进行了体重指数 (BMI) 的计算和血清瘦素水平的测量。结–125]; P < 0.001) 与对照组相比。血清瘦素水平与疾病活动性或残疾程度无关。结论与对照组相比，MS 患者具有显着更高的 BMI 和更高的血清瘦素水平。