As a commonly used anesthetic agent, midazolam has the properties of water-soluble, rapid onset, and short duration of action. With the rapid development in the field of neuroimaging, numerous studies have investigated how midazolam acts on the human brain to induce the alteration of consciousness. However, the neural bases of midazolam-induced sedation or anesthesia remain beginning to be understood in detail. In this review, we summarize findings from neuroimaging studies that have used midazolam to study altered consciousness at different levels and content. We also compare the results to those of neuroimaging studies using diverse anesthetic agents and describe the common neural correlates of anesthetic-induced alteration of consciousness.

中文翻译：

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咪达唑仑对人脑的神经心理药理作用

作为一种常用的麻醉剂，咪达唑仑具有水溶性，起效快和作用时间短的特性。随着神经成像领域的快速发展，许多研究已经研究了咪达唑仑如何作用于人脑以诱导意识改变。但是，咪达唑仑引起的镇静或麻醉的神经基础仍然开始被详细了解。在这篇综述中，我们总结了神经影像学研究的发现，这些研究已经使用咪达唑仑研究了不同水平和内容的意识改变。我们还将结果与使用多种麻醉剂进行神经影像学研究的结果进行比较，并描述麻醉药引起的意识改变的常见神经相关性。