With CA16, enterovirus-71 is the causative agent of hand foot and mouth disease (HFMD) which occurs mostly in children under 5 years-old and responsible of several outbreaks since a decade. Most of the time, HFMD is a mild disease but can progress to severe complications such as meningitis, brain stem encephalitis, acute flaccid paralysis (AFP) and even death; EV71 has been identified in all severe cases. Therefore, it is actually one of the most public health issues that threatens children’s life. $$3{\rm C}^{{\rm pro}}$$ is a protease which plays important functions in EV71 infection. To date, a lot of $$3{\rm C}^{{\rm pro}}$$ inhibitors have been tested but none of them has been approved yet. Therefore, a drug screening is still an utmost importance in order to treat and/or prevent EV71 infections. This work highlights the EV71 life cycle, $$3{\rm C}^{{\rm pro}}$$ functions and $$3{\rm C}^{{\rm pro}}$$ inhibitors recently screened. It permits to well understand all mechanisms about $$3{\rm C}^{{\rm pro}}$$ and consequently allow further development of drugs targeting $$3{\rm C}^{{\rm pro}}$$ . Thus, this review is helpful for screening of more new $$3{\rm C}^{{\rm pro}}$$ inhibitors or for designing analogues of well known $$3{\rm C}^{{\rm pro}}$$ inhibitors in order to improve its antiviral activity.

中文翻译：

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肠道病毒 71 \(3{\rm C}^{{\rm pro}}\) 靶向抑制剂的最新进展


与 CA16 一样，肠道病毒 71 是手足口病 (HFMD) 的病原体，手足口病主要发生在 5 岁以下儿童中，十年来曾多次暴发手足口病。大多数时候，手足口病是一种轻微的疾病，但可以发展为严重的并发症，如脑膜炎、脑干脑炎、急性弛缓性麻痹（AFP），甚至死亡；所有重症病例均已发现 EV71 型病毒。因此，它实际上是威胁儿童生命最严重的公共卫生问题之一。 $$3{\rm C}^{{\rm pro}}$$是一种蛋白酶，在EV71感染中发挥重要作用。迄今为止，许多$$3{\rm C}^{{\rm pro}}$$抑制剂已经过测试，但尚未获得批准。因此，药物筛选对于治疗和/或预防 EV71 感染仍然至关重要。这项工作重点介绍了 EV71 的生命周期、$$3{\rm C}^{{\rm pro}}$$ 功能和最近筛选的 $$3{\rm C}^{{\rm pro}}$$ 抑制剂。它允许很好地理解$$3{\rm C}^{{\rm pro}}$$的所有机制，从而允许进一步开发针对$$3{\rm C}^{{\rm pro}}$$的药物。因此，本综述有助于筛选更多新的 $$3{\rm C}^{{\rm pro}}$$ 抑制剂或设计众所周知的 $$3{\rm C}^{{\rm pro} 的类似物}$$抑制剂以提高其抗病毒活性。