>Patients with functional gastrointestinal disorders have a high psychiatric co-morbidity. This study aimed to investigate and characterise gastrointestinal symptoms in relation to depressive symptoms and trait anxiety in a well-defined population of young adult psychiatric outpatients and healthy controls. Gastrointestinal symptoms were assessed with the Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome (GSRS-IBS). Depressive symptoms were assessed with the Montgomery-Åsberg Depression Rating Scale- Self assessment (MADRS-S). Trait anxiety was estimated with three of the Swedish universities of Personality (SSP) scales: Somatic trait anxiety, Psychic trait anxiety and Stress susceptibility. Self-ratings were collected from 491 young adult psychiatric outpatients and 85 healthy controls. Gastrointestinal symptom severity was compared between patients with and without current psychotropic medication and controls. Associations between gastrointestinal symptoms, depressive symptoms and trait anxiety were assessed using Spearman’s coefficients and generalized linear models adjusting for possible confounders (sex, body mass index, bulimia nervosa). Patients, with and without current psychotropic medication, reported significantly more gastrointestinal symptoms than controls. In the generalized linear models, total MADRS-S score (p < 0.001), Somatic trait anxiety (p < 0.001), Psychic trait anxiety (p = 0.002) and Stress susceptibility (p = 0.002) were independent predictors of the total GSRS-IBS score. Further exploratory analysis using unsupervised learning revealed a diverse spectrum of symptoms that clustered into six groups. Gastrointestinal symptoms are both highly prevalent and diverse in young adult psychiatric outpatients, regardless of current psychotropic medication. Depressive symptom severity and degree of trait anxiety are independently related to the total gastrointestinal symptom burden.

中文翻译：

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年轻人胃肠道症状、抑郁症状和特质焦虑的横断面研究


>患有功能性胃肠道疾病的患者具有较高的精神共病率。本研究旨在调查和表征明确的年轻成年精神科门诊患者和健康对照人群中与抑郁症状和特质焦虑相关的胃肠道症状。使用肠易激综合征胃肠道症状评定量表（GSRS-IBS）评估胃肠道症状。抑郁症状通过蒙哥马利-阿斯伯格抑郁评定量表-自我评估（MADRS-S）进行评估。特质焦虑是用瑞典大学人格（SSP）量表中的三个来评估的：躯体特质焦虑、心理特质焦虑和压力敏感性。自评收集自 491 名年轻成人精神科门诊患者和 85 名健康对照者。对目前使用和未使用精神药物的患者和对照组之间的胃肠道症状严重程度进行了比较。使用斯皮尔曼系数和广义线性模型评估胃肠道症状、抑郁症状和特质焦虑之间的关联，并调整可能的混杂因素（性别、体重指数、神经性贪食症）。无论目前是否服用精神药物，患者报告的胃肠道症状均明显多于对照组。在广义线性模型中，MADRS-S 总分 (p < 0.001)、躯体特质焦虑 (p < 0.001)、心理特质焦虑 (p = 0.002) 和压力敏感性 (p = 0.002) 是 GSRS 总分的独立预测因子IBS 评分。使用无监督学习的进一步探索性分析揭示了多种症状，可分为六组。 无论目前使用何种精神药物，胃肠道症状在年轻成人精神科门诊患者中都非常普遍且多样化。抑郁症状的严重程度和特质焦虑的程度与总胃肠道症状负担独立相关。