Asthma has been shown to be related to an increased risk of invasive pneumococcal disease (IPD), although the results remain inconclusive. Therefore, we performed a meta-analysis to determine whether asthma increases the risk of IPD. This meta-analysis was performed to validate and strengthen the association between asthma and IPD. PubMed, EMBASE, Web of Science, and the reference lists of all relevant articles and books were screened until May 2019. Two authors independently assessed eligibility and study quality and extracted data. A common odds ratio was estimated using a random-effects meta-analysis model of aggregated published data. A total of eight studies with 8877 IPD cases and 78,366 controls were included. Our meta-analysis showed that asthma was significantly associated with the increased risk of IPD (OR 2.44 [95% CI, 2.02–2.96]). The children with asthma (0–17 years old) (OR 2.86 [95% CI 1.80–4.55]) had a higher risk of IPD susceptibility compared with the adult patients (≥ 18 years old) (OR 2.45 [95% CI 1.98–3.03]). Results of this meta-analysis indicated that the patients with asthma had a higher risk of IPD susceptibility, especially among the children with asthma.

中文翻译：

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哮喘与侵袭性肺炎球菌疾病风险之间的关联：系统评价和荟萃分析

哮喘与浸润性肺炎球菌疾病（IPD）风险增加有关，尽管结果尚无定论。因此，我们进行了荟萃分析，以确定哮喘是否增加了IPD的风险。进行这项荟萃分析，以验证和加强哮喘与IPD之间的关联。筛选了PubMed，EMBASE，Web of Science以及所有相关文章和书籍的参考清单，直到2019年5月为止。两名作者独立评估了资格和研究质量并提取了数据。使用汇总的已发布数据的随机效应荟萃分析模型估算常见优势比。总共包括8个研究，涉及8877个IPD病例和78,366个对照。我们的荟萃分析显示，哮喘与IPD风险增加显着相关（OR 2.44 [95％CI，2.02-2.96]）。与成年患者（≥18岁）相比，哮喘儿童（0-17岁）（OR 2.86 [95％CI 1.80-4.55]）患IPD的风险更高（OR 2.45 [95％CI 1.98-CI] 3.03]）。这项荟萃分析的结果表明，哮喘患者患IPD的风险更高，尤其是在哮喘患儿中。