The UV-visible photodegradation of Naproxen (6-methoxy-α-methyl-2-naphthaleneacetic acid, CAS: 22204-53-1), one of the most used and detected non-steroidal anti-inflammatory drugs (NSAIDs) in the world, and its ecotoxicological consequences were investigated in an aqueous medium. The photo-transformation products were analyzed and the structures of photoproducts were elucidated using gas chromatography coupled with tandem mass spectrometry (GC-MS/MS) and high-performance liquid chromatography coupled with ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR-MS). Seven photoproducts were detected and characterized, photo-transformation mechanisms have been postulated to rationalize their formation under irradiation. In silico Q.S.A.R. (Quantitative Structure-Activity Relationship) toxicity predictions were performed with the Toxicity Estimation Software Tool (T.E.S.T.) and in vitro assays were carried out on Vibrio fischeri bacteria. Some of the obtained photoproducts exhibit higher potential toxicity than Naproxen itself but the whole toxicity of the irradiated solution is not of major concern.

中文翻译：

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萘普生在水中的紫外可见光降解——光产物和潜在毒性的结构阐明

萘普生（6-甲氧基-α-甲基-2-萘乙酸，CAS：22204-53-1）的紫外可见光降解，这是世界上使用和检测最多的非甾体抗炎药（NSAIDs）之一，并在水性介质中研究了其生态毒理学后果。使用气相色谱-串联质谱（GC-MS/MS）和高效液相色谱-超高分辨率傅里叶变换离子回旋共振质谱（LC- FTICR-MS）。检测并表征了七种光产物，推测光转化机制可以使它们在辐照下的形成合理化。计算机 QSAR 使用毒性估计软件工具 (TEST) 进行（定量结构-活性关系）毒性预测，并对费氏弧菌细菌进行体外测定。一些获得的光产品表现出比萘普生本身更高的潜在毒性，但辐照溶液的整体毒性并不是主要问题。