Survivors of breast and other cancers often report protracted difficulty in performing tasks involving concentration and memory, even years after the completion of treatment. The current study investigated whether cancer and treatment history is associated with deficits in sensory filtering (gating out) and sensory memory (gating in), early processes in stimulus processing that may contribute to difficulties in later remembering. A group of breast cancer survivors and age-matched healthy control participants (mean age 54 years) underwent testing with paired-click and oddball tasks while electroencephalographic (EEG) signals were recorded. The survivors showed relatively poor inhibition of redundant sensory stimulation (P50 suppression). Dipole source analysis localized the survivors' impairment to the hippocampus, with preservation of function in gating mechanisms of the frontal lobe and auditory cortex. Survivors also showed disruption to sensory memory processes needed to register novel information in an otherwise uniform auditory environment (mismatch negativity). The findings suggest that survivors experience deficits in early, automatic mechanisms of sensory gating, which may trigger a cascade of later perceived attentional and memory deficits. If our account is accurate, ideal therapies might aim to restore early inhibitory processes, such as those gauged by P50 suppression.

中文翻译：

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乳腺癌幸存者的感觉过滤和感觉记忆

乳腺癌和其他癌症的幸存者经常报告在执行涉及注意力和记忆力的任务方面存在长期困难，即使在完成治疗数年后也是如此。目前的研究调查了癌症和治疗史是否与感觉过滤（门禁）和感觉记忆（门禁）缺陷有关，刺激处理的早期过程可能导致后期记忆困难。一组乳腺癌幸存者和年龄匹配的健康对照参与者（平均年龄 54 岁）接受了配对点击和古怪任务的测试，同时记录了脑电图 (EEG) 信号。幸存者对多余的感觉刺激（P50抑制）表现出相对较差的抑制。偶极子源分析将幸存者的损伤定位于海马体，保留额叶和听觉皮层门控机制的功能。幸存者还表现出对在其他统一的听觉环境中注册新信息所需的感觉记忆过程的破坏（错配消极性）。研究结果表明，幸存者在感觉门控的早期自动机制方面存在缺陷，这可能会引发一系列后来感知到的注意力和记忆缺陷。如果我们的描述是准确的，理想的疗法可能旨在恢复早期抑制过程，例如通过 P50 抑制来衡量的那些。研究结果表明，幸存者在感觉门控的早期自动机制方面存在缺陷，这可能会引发一系列后来感知到的注意力和记忆缺陷。如果我们的描述是准确的，理想的疗法可能旨在恢复早期抑制过程，例如通过 P50 抑制来衡量的那些。研究结果表明，幸存者在感觉门控的早期自动机制方面存在缺陷，这可能会引发一系列后来感知到的注意力和记忆缺陷。如果我们的描述是准确的，理想的疗法可能旨在恢复早期抑制过程，例如通过 P50 抑制来衡量的那些。