Oscillations in the granule cell layer (GCL) of the cerebellar cortex have been related to behavior and could facilitate communication with the cerebral cortex. These local field potential (LFP) oscillations, strong at 4–12 Hz in the rodent cerebellar cortex during awake immobility, should also be an indicator of an underlying influence on the patterns of the cerebellar cortex neuronal firing during rest. To address this hypothesis, cerebellar cortex LFPs and simultaneous single-neuron activity were collected during LFP oscillatory periods in the GCL of awake resting rats. During these oscillatory episodes, different types of units across the GCL and Purkinje cell layers showed variable phase-relation with the oscillatory cycles. Overall, 74% of the Golgi cell firing and 54% of the Purkinje cell simple spike (SS) firing were phase-locked with the oscillations, displaying a clear phase relationship. Despite this tendency, fewer Golgi cells (50%) and Purkinje cell’s SSs (25%) showed an oscillatory firing pattern. Oscillatory phase-locked spikes for the Golgi and Purkinje cells occurred towards the peak of the LFP cycle. GCL LFP oscillations had a strong capacity to predict the timing of Golgi cell spiking activity, indicating a strong influence of this oscillatory phenomenon over the GCL. Phase-locking was not as prominent for the Purkinje cell SS firing, indicating a weaker influence over the Purkinje cell layer, yet a similar phase relation. Overall, synaptic activity underlying GCL LFP oscillations likely exert an influence on neuronal population firing patterns in the cerebellar cortex in the awake resting state and could have a preparatory neural network shaping capacity serving as a neural baseline for upcoming cerebellar operations.

中文翻译：

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清醒大鼠的小脑皮层 4-12 Hz 振荡和单位相位关系

小脑皮层颗粒细胞层 (GCL) 的振荡与行为有关，可以促进与大脑皮层的交流。这些局部场电位 (LFP) 振荡，在清醒不动时在啮齿动物小脑皮层中以 4-12 Hz 强烈，也应该是对休息期间小脑皮层神经元放电模式潜在影响的指标。为了解决这一假设，在清醒休息大鼠的 GCL 中的 LFP 振荡期间收集了小脑皮层 LFP 和同时的单神经元活动。在这些振荡事件中，GCL 和浦肯野细胞层中不同类型的单元显示出与振荡周期的可变相位关系。全面的，74% 的高尔基细胞放电和 54% 的浦肯野细胞简单尖峰 (SS) 放电与振荡锁相，显示出清晰的相位关系。尽管有这种趋势，较少的高尔基细胞 (50%) 和浦肯野细胞的 SSs (25%) 显示出振荡的放电模式。高尔基体和浦肯野细胞的振荡锁相尖峰出现在 LFP 周期的峰值。GCL LFP 振荡具有很强的预测高尔基细胞尖峰活动时间的能力，表明这种振荡现象对 GCL 有很强的影响。浦肯野细胞 SS 发射的锁相不那么突出，表明对浦肯野细胞层的影响较弱，但具有相似的相位关系。全面的，