Background and Aim: Few reports have investigated the association between metabolic abnormalities (obesity and related metabolic syndrome) and total serum IgE concentrations. Methods: This cross-sectional study included a random sample of 1,516 adult individuals (44.7% men, aged 18–91 years, median 52 years) from a single municipality in Spain. Serum IgE was measured in the ADVIA Centaur system. Atopy was defined by the presence of positive skin prick tests to a panel of common aeroallergens in the area. Body mass index and data related to the definition of metabolic syndrome were obtained from all participants. Alcohol consumption, smoking, and regular physical exercise were assessed by a questionnaire. Results: Atopy (present in 21.9% of 1,514 evaluable individuals) was the strongest factor determining serum IgE concentrations. Male sex and heavy alcohol drinking were independently associated with higher IgE concentrations, particularly in the non-atopic individuals. Body mass index was positively associated with IgE concentrations, independent of potential confounders, although the effect was only evident among non-atopic individuals. In that group, median IgE concentrations in normal-weight and obese individuals were 15 and 24 kU/L, respectively (p #x3c; 0.001); likewise, obesity was associated with high (#x3e;100 kU/L) IgE concentrations after adjusting for potential confounders (odds ratio: 1.79, 95% confidence interval: 1.26–2.56, p = 0.001). The presence of metabolic syndrome and its components, particularly abdominal obesity and hyperglycaemia, was also positively and independently associated with higher IgE concentrations in non-atopic individuals. Conclusions: Obesity and metabolic syndrome components are associated with high total serum IgE concentrations, particularly in non-atopic individuals.
Int Arch Allergy Immunol

中文翻译：

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影响成人总血清 IgE 的因素：肥胖和相关代谢疾病的作用

背景和目的：很少有报告研究代谢异常（肥胖和相关代谢综合征）与血清总 IgE 浓度之间的关系。方法：这项横断面研究包括来自西班牙一个城市的 1,516 名成年个体（男性占 44.7%，年龄在 18-91 岁，中位数为 52 岁）的随机样本。在 ADVIA Centaur 系统中测量血清 IgE。特应性的定义是对该区域的一组常见空气过敏原的皮肤点刺试验呈阳性。从所有参与者那里获得了与代谢综合征定义相关的体重指数和数据。通过问卷评估饮酒、吸烟和定期体育锻炼。结果：特应性（存在于 1,514 名可评估个体中的 21.9%）是决定血清 IgE 浓度的最强因素。男性和大量饮酒与较高的 IgE 浓度独立相关，特别是在非特应性个体中。体重指数与 IgE 浓度呈正相关，独立于潜在的混杂因素，尽管这种影响仅在非特应性个体中很明显。在该组中，正常体重和肥胖个体的 IgE 浓度中位数分别为 15 和 24 kU/L ( p #x3c; 0.001)；同样，在调整潜在混杂因素后，肥胖与高 (#x3e;100 kU/L) IgE 浓度相关（优势比：1.79，95% 置信区间：1.26-2.56，p= 0.001）。代谢综合征及其组成部分的存在，尤其是腹部肥胖和高血糖症，也与非特应性个体中较高的 IgE 浓度呈正相关且独立相关。结论：肥胖和代谢综合征成分与高总血清 IgE 浓度相关，特别是在非特应性个体中。
Int Arch 过敏免疫