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E-test determination of antifungal susceptibility of Candida species isolated from turkeys
Journal of Veterinary Research ( IF 1.8 ) Pub Date : 2020-11-10 , DOI: 10.2478/jvetres-2020-0072
Ireneusz Sokół 1 , Stanisław Tokarzewski 2 , Kamila Bobrek 3 , Andrzej Gaweł 3
Affiliation  

Abstract Introduction Candida species are a natural component of the intestinal tract microflora, but in favourable conditions they can cause superficial, mucosal, or even systemic candidiasis. Poultry production might be a source of human drug-resistant yeast infections, including Candida spp. The limited data concerning the antifungal susceptibility of poultry Candida isolates prompted us to carry out research to determine the susceptibility of isolates from turkey intestinal tracts. Method and Materials The beak cavity, crop and cloaca were swabbed of 580 turkeys from 58 flocks in western Poland. The susceptibility tests were conducted using the E-test method with amphotericin B, fluconazole, itraconazole, and voriconazole on 52 isolates of C. albicans, C. catenulata, C. glabrata, C. palmioleophila, C. rugosa, C. krusei and C. lusitaniae. Results All isolates were susceptible to voriconazole. According to the MIC values obtained for amphotericin B and fluconazole, all Candida spp. isolates were classified as susceptible according to the described breakpoints except for C. krusei, which was the only isolate that was amphotericin B-, fluconazole- and itraconazole-resistant. The susceptibility to itraconazole varied: 11 of the Candida isolates were susceptible (21.1%), 29 were dose-dependently susceptible (55.8%), and 12 isolates were resistant (23.1%). Conclusion There are few resistant strains of Candida in turkeys, and the drug resistance varies. When Candida passes from turkeys to humans, there is a wide range of antifungal treatment options.

中文翻译:

从火鸡中分离的念珠菌抗真菌敏感性的 E 试验测定

摘要 引言 念珠菌属是肠道菌群的天然成分,但在有利条件下,它们可引起浅表、黏膜甚至全身念珠菌病。家禽生产可能是人类耐药酵母菌感染的一个来源,包括念珠菌属。关于家禽念珠菌分离株抗真菌敏感性的有限数据促使我们开展研究以确定火鸡肠道分离株的敏感性。方法和材料 对波兰西部 58 只火鸡的 580 只火鸡的喙腔、嗉囊和泄殖腔进行擦拭。药敏试验采用 E-test 方法,使用两性霉素 B、氟康唑、伊曲康唑和伏立康唑对 52 株白色念珠菌、链状念珠菌、光滑念珠菌、棕榈念珠菌、皱褶念珠菌、克氏念珠菌和念珠菌. 卢西塔尼亚。结果所有菌株均对伏立康唑敏感。根据两性霉素 B 和氟康唑的 MIC 值,所有念珠菌属。根据所描述的断点,分离株被分类为易感菌株,但克氏梭菌除外,它是唯一对两性霉素 B、氟康唑和伊曲康唑耐药的分离株。对伊曲康唑的敏感性各不相同:11 株念珠菌是敏感的(21.1%),29 株是剂量依赖性敏感的(55.8%),12 株是耐药的(23.1%)。结论 火鸡中念珠菌耐药菌株较少,耐药性参差不齐。当念珠菌从火鸡传给人类时,有多种抗真菌治疗选择。根据所描述的断点,分离株被分类为易感菌株,但克氏梭菌除外,它是唯一对两性霉素 B、氟康唑和伊曲康唑耐药的分离株。对伊曲康唑的敏感性各不相同:11 株念珠菌是敏感的(21.1%),29 株是剂量依赖性敏感的(55.8%),12 株是耐药的(23.1%)。结论 火鸡中念珠菌耐药菌株较少,耐药性参差不齐。当念珠菌从火鸡传给人类时,有多种抗真菌治疗选择。根据所描述的断点,分离株被分类为易感菌株,但克氏梭菌除外,它是唯一对两性霉素 B、氟康唑和伊曲康唑耐药的分离株。对伊曲康唑的敏感性各不相同:11 株念珠菌是敏感的(21.1%),29 株是剂量依赖性敏感的(55.8%),12 株是耐药的(23.1%)。结论 火鸡中念珠菌耐药菌株较少,耐药性参差不齐。当念珠菌从火鸡传给人类时,有多种抗真菌治疗选择。1%),29 株呈剂量依赖性敏感(55.8%),12 株耐药(23.1%)。结论 火鸡中念珠菌耐药菌株较少,耐药性参差不齐。当念珠菌从火鸡传给人类时,有多种抗真菌治疗选择。1%),29 株呈剂量依赖性敏感(55.8%),12 株耐药(23.1%)。结论 火鸡中念珠菌耐药菌株较少,耐药性参差不齐。当念珠菌从火鸡传给人类时,有多种抗真菌治疗选择。
更新日期:2020-11-10
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