The dissolution properties of l-leucine (L-Leu) supplements with hydrophobic surfaces were improved by coating particles with hydrophilic fumed SiO₂ nanoparticles (Aerosil 200FAD) using ultrasonic irradiation in high-pressure liquid carbon dioxide (CO₂). Shock waves generated by the collapse of cavitation bubbles induced by ultrasonic irradiation accelerated the deagglomeration and dispersion of SiO₂ nanoparticles and achieved dry-particle coating in high-pressure liquid CO₂. The dissolution rate of the l-Leu microparticles was increased by coating with SiO₂ nanoparticles. The effects of the experimental conditions (size and concentration of the SiO₂ nanoparticles, coating method, depressurizing method, and ultrasonic irradiation time) on the morphology and dissolution rate of the composite particles were also investigated.

通过在高压液态二氧化碳（CO ₂）中通过超声辐照，用亲水性气相SiO ₂纳米颗粒（Aerosil 200FAD）涂覆颗粒，可以改善具有疏水表面的1-亮氨酸（L-Leu）补充剂的溶解特性。超声辐射引起的空化气泡破裂产生的冲击波加速了SiO ₂纳米颗粒的解聚和分散，并在高压液态CO _2中实现了干颗粒涂层。通过用SiO ₂纳米颗粒涂覆提高了1- Leu微粒的溶解速率。实验条件的影响（SiO的大小和浓度_{还研究了2种}纳米颗粒，涂覆方法，降压方法和超声辐照时间对复合颗粒的形貌和溶解速率的影响。