Abstract The nanoparticles (NPs) from polyvinyl butyrate (PVBu) which can work as an orally applicable donor of butyrate for intestine were prepared. Immunotolerance inducing molecules such as vitamin D3 and all-trans retinoic acid (ATRA) were incorporated into PVBu NPs. The alteration in populations and numbers of DC103+ dendritic cells (DC) and regulatory T (Treg) cells in intestinal immune tissues were examined after oral administration of NPs. It was found that NPs reduced the population of CD103+ DC and Treg cells in Peyer's patched in lower part of the intestine and inversely increased the population of CD103+ DC in mesenteric lymph node (MLN), while the population of Treg cells in MLN was unchanged. These observations indicate that NPs may enhance the immunotolerance at MLN and lamina propria toward luminal antigens, indicating the promising features of PVBu NPs as therapeutics of allergy and autoimmune diseases.

中文翻译：

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聚丁酸乙烯酯纳米粒与免疫抑制维生素对肠道免疫细胞数量改变的影响

摘要 制备了聚丁酸乙烯酯（PVBu）纳米颗粒（NPs），可作为肠道丁酸的口服供体。免疫耐受诱导分子如维生素 D3 和全反式视黄酸 (ATRA) 被纳入 PVBu NPs。口服NPs后，检测肠道免疫组织中DC103+树突状细胞（DC）和调节性T（Treg）细胞的数量和数量的变化。发现NPs减少了小肠下部Peyer's补丁中CD103+ DC和Treg细胞的数量，并反向增加了肠系膜淋巴结（MLN）中CD103+ DC的数量，而MLN中Treg细胞的数量没有变化。这些观察结果表明，NPs 可能会增强 MLN 和固有层对管腔抗原的免疫耐受性，