Cardiocerebrovascular disease is a collective term for cardiovascular and cerebrovascular diseases. Because of the complex mechanisms involved in cardiocerebrovascular diseases, limited effective treatments have been developed. With advancements in precision medicine, studies have focused on long noncoding RNAs (lncRNAs) in cerebrovascular diseases. LncRNAs, which are over 200 nucleotides long, regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels. Moreover, lncRNAs play pivotal roles in the progression of cardiocerebrovascular diseases. For example, recent studies suggested that abnormal expression of lncRNAs are closely related to the occurrence and progression of these diseases. LncRNAs regulate gene expression by specifically binding to mRNA to modulate disease progression, serving as biomarkers for the diagnosis and prognosis of cardiocerebrovascular diseases. In this review, we discuss the roles, mechanisms, and clinical value of lncRNAs in cardiocerebrovascular diseases, providing a new perspective for the diagnosis and treatment of the diseases.

心脑血管疾病是心脑血管疾病的统称。由于心脑血管疾病涉及的复杂机制，已开发出有限的有效治疗方法。随着精准医学的进步，研究集中在脑血管疾病中的长链非编码 RNA (lncRNA)。长度超过 200 个核苷酸的 LncRNA 在表观遗传、转录和转录后水平上调节基因表达。此外，lncRNAs 在心脑血管疾病的进展中发挥着关键作用。例如，最近的研究表明，lncRNAs的异常表达与这些疾病的发生和发展密切相关。LncRNA 通过特异性结合 mRNA 来调节基因表达，从而调节疾病进展，可作为心脑血管疾病诊断和预后的生物标志物。本文就lncRNA在心脑血管疾病中的作用、作用机制及临床价值进行探讨，为疾病的诊治提供新的视角。