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Improved green biosynthesis of chitosan decorated Ag- and Co3O4-nanoparticles: A relationship between surface morphology, photocatalytic and biomedical applications
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 4.2 ) Pub Date : 2020-11-10 , DOI: 10.1016/j.nano.2020.102331
Mahsa Kiani 1 , Navid Rabiee 1 , Mojtaba Bagherzadeh 1 , Amir Mohammad Ghadiri 1 , Yousef Fatahi 2 , Rassoul Dinarvand 3 , Thomas J Webster 4
Affiliation  

AgNPs@Chitosan and Co3O4-NPs@Chitosan were fabricated with Salvia hispanica. Results showed MZI values of 5 and 30 mm for Co3O4-NPs- and AgNPs@Chitosan against S. aureus, and 15 and 21 mm for Co3O4-NPs- and AgNPs@Chitosan against E. coli (24 h, 20 μg/mL), respectively. MTT assays showed up to 80% and 90%, 71% and 75%, and 91% and 94% mammalian cell viability for the green synthesized, chemically synthesized AgNPs and green synthesized AgNPs@Chitosan for HEK-293 and PC12 cells, respectively, and 70% and 71%, 59% and 62%, and 88% and 73% for the related Co3O4-NPs (24 h, 20 μg/mL). The photocatalytic activities showed dye degradation after 135 and 105 min for AgNPs@Chitosan and Co3O4-NPs@Chitosan, respectively. FESEM results showed differences in particle sizes (32 ± 3.0 nm for the AgNPs and 41 ± 3.0 nm for the Co3O4NPs) but AFM results showed lower roughness of the AgNPs@Chitosan (7.639 ± 0.85 nm) compared to Co3O4NPs@Chitosan (9.218 ± 0.93 nm), which resulted in potential biomedical applications.



中文翻译:

改善壳聚糖修饰的 Ag 和 Co3O4 纳米颗粒的绿色生物合成:表面形态、光催化和生物医学应用之间的关系

AgNPs@Chitosan 和 Co 3 O 4 -NPs@Chitosan 是用西班牙鼠尾草制造的。结果表明5 MZI值和钴30毫米3 ö 4 -NPs-和的AgNPs @壳聚糖对金黄色葡萄球菌,和15和21毫米共3 ö 4 -NPs-和的AgNPs @对壳聚糖大肠杆菌(24小时, 20 μg/mL),分别。MTT 分析表明,对于 HEK-293 和 PC12 细胞,绿色合成、化学合成的 AgNPs 和绿色合成的 AgNPs@Chitosan 的哺乳动物细胞活力分别高达 80% 和 90%、71% 和 75% 以及 91% 和 94%。和 70% 和 71%、59% 和 62% 以及 88% 和 73% 的相关 Co 3 O 4-NPs(24 小时,20 微克/毫升)。光催化活性表明,AgNPs@Chitosan 和 Co 3 O 4 -NPs@Chitosan在 135 分钟和 105 分钟后染料降解。FESEM 结果显示粒径不同(AgNPs 为 32 ± 3.0 nm,Co 3 O 4 NPs为 41 ± 3.0 nm ),但 AFM 结果显示 AgNPs@Chitosan 的粗糙度(7.639 ± 0.85 nm)与 Co 3 O相比较低4 NPs@Chitosan (9.218 ± 0.93 nm),这导致了潜在的生物医学应用。

更新日期:2020-11-10
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