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Single source precursor synthesized CuS nanoparticles for NIR phototherapy of cancer and photodegradation of organic carcinogen
Journal of Photochemistry and Photobiology B: Biology ( IF 5.4 ) Pub Date : 2020-11-11 , DOI: 10.1016/j.jphotobiol.2020.112084
Mehwish Arshad , Zhaojie Wang , Jamal Abdul Nasir , Eric Amador , Mingwu Jin , Haibin Li , Zhigang Chen , Zia ur Rehman , Wei Chen

Herein, we report cost effective and body compatible CuS nanoparticles (NPs) derived from a single source precursor as photothermal agent for healing deep cancer and photocatalytic remediation of organic carcinogens. These NPs efficiently kill MCF7 cells (both in vivo and in vitro) under NIR irradiation by raising the temperature of tumor cells. Such materials can be used for the treatment of deep cancer as they can produce a heating effect using high wavelength and deeply penetrating NIR radiation. Furthermore, CuS NPs under solar light irradiation efficiently convert p-nitrophenol (PNP), an environmental carcinogen, to p-aminophenol (PAP) of pharmaceutical implication. In a nutshell, CuS can be used for the treatment of deep cancer and for the remediation of carcinogenic pollutants. There seems an intrinsic connection between the two functions of CuS NPs that need to be explored in length.



中文翻译:

单源前驱体合成的CuS纳米粒子用于NIR癌症光疗和有机致癌物的光降解

在本文中,我们报告了具有成本效益且与人体相容的CuS纳米颗粒(NPs),它们来自单一来源的前体,可作为光热剂治疗深部癌症和对有机致癌物进行光催化修复。这些NP通过提高肿瘤细胞的温度在NIR照射下有效杀死MCF7细胞(体内体外)。此类材料可用于治疗深部癌症,因为它们可以使用高波长和深穿透性的NIR辐射产生加热效果。此外,在阳光照射下,CuS NPs可以有效地将环境致癌物硝基苯酚(PNP)转化为p-氨基苯酚(PAP)的药物意义。简而言之,CuS可用于治疗深层癌症和修复致癌污染物。CuS NP的两个功能之间似乎存在内在联系,需要对其进行深入探讨。

更新日期:2020-11-12
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