Immunology Letters ( IF 3.3 ) Pub Date : 2020-11-10 , DOI: 10.1016/j.imlet.2020.11.003 Hui-Min Liu 1 , Le-le Ma 1 , Bo Cao 1 , Jun-Zhi Lin 2 , Li Han 1 , Chun-Yu Li 3 , Run-Chun Xu 1 , Ding-Kun Zhang 4
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In abnormal glycosylation, molecules of glucose or other carbohydrates in living organisms are inappropriately attached to proteins, which causes protein denaturation. Abnormal glycosylation modification is known to directly or indirectly affect the tumor escape process, but very few studies have been performed on whether protein glycosylation changes the structure and function of immune cells and immune molecules and thereby regulates the occurrence and development of tumor escape. Therefore, this article summarizes the effect of the immune system on tumor escape in association with the abnormal glycosylation process from an immunological perspective.
中文翻译：
异常糖基化修饰在肿瘤免疫中的作用研究进展
在异常的糖基化中，生物体内的葡萄糖或其他碳水化合物分子不恰当地附着在蛋白质上，导致蛋白质变性。已知异常的糖基化修饰直接或间接影响肿瘤逃逸过程，但关于蛋白质糖基化是否改变免疫细胞和免疫分子的结构和功能从而调节肿瘤逃逸的发生和发展的研究很少。因此，本文从免疫学角度总结了与异常糖基化过程相关的免疫系统对肿瘤逃逸的影响。
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