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Simulation of hemo- and biochemical toxicities associated with chronic inhalation exposure to 2,2-Dichlorovinyl dimethyl phosphate (DDVP) in Wistar rat
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-11-11 , DOI: 10.1016/j.etap.2020.103547
Kehinde Olusola Awotunsin , Olayinka Ayotunde Oridupa , John O. Ogunsola , Ayobami Deborah Obisesan , Adebowale Bernard Saba

DDVP is a commonly used pesticide in Nigeria and those involved with DDVP manufacturing, packaging or utilizing facilities seldom use PPE to limit pesticide exposure. The study aim was to determine the impact of chronic exposure to DDVP by monitoring hematological and biochemical changes in Wistar rats. Male rats (n = 60; 150−180 g) were exposed to graded DDVP concentrations (0%, 20 %, 40 %, 60 %, 80 % and 100 %) via inhalation route for 60 days. Body weights were initially measured and then at 20-day intervals. Blood samples were collected for hematology and serum biochemistry on day 61. Results showed significant (p < 0.05) polycythemia, neutrophilia, thrombocytosis, hepatic and renal derangement in rats exposed to DDVP. Also, albumin, AST, ALP, creatinine, blood urea nitrogen, bilirubin levels and dyslipidemia significantly increased. Cholinergic signs and stunted growth were observed in higher concentrations. Study emphasized hazards of DDVP mishandling and risks of non-compliance with PPE use by workers in-contact with DDVP, as well as misuse/abuse in animals.



中文翻译:

Wistar大鼠与慢性吸入暴露于2,2-二氯乙烯基磷酸二甲酯(DDVP)相关的血液和生化毒性模拟

DDVP是尼日利亚的一种常用农药,涉及DDVP生产,包装或利用设施的人员很少使用PPE来限制农药暴露。该研究的目的是通过监测Wistar大鼠的血液和生化变化来确定长期接触DDVP的影响。雄性大鼠(n = 60; 150-180 g)通过吸入途径暴露于分级DDVP浓度(0%,20%,40%,60%,80%和100%)中60天。首先测量体重,然后每隔20天测量一次。在第61天收集血样用于血液学和血清生化。结果显示,暴露于DDVP的大鼠有明显的(p <0.05)红细胞增多症,中性粒细胞增多,血小板增多,肝和肾紊乱。此外,白蛋白,AST,ALP,肌酐,血尿素氮,胆红素水平和血脂异常明显增加。在较高浓度下观察到胆碱能体征和发育迟缓。研究强调了DDVP处理不当的危险以及与DDVP接触的工人不遵守PPE的风险以及在动物中的滥用/滥用。

更新日期:2020-11-26
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