DDVP is a commonly used pesticide in Nigeria and those involved with DDVP manufacturing, packaging or utilizing facilities seldom use PPE to limit pesticide exposure. The study aim was to determine the impact of chronic exposure to DDVP by monitoring hematological and biochemical changes in Wistar rats. Male rats (n = 60; 150−180 g) were exposed to graded DDVP concentrations (0%, 20 %, 40 %, 60 %, 80 % and 100 %) via inhalation route for 60 days. Body weights were initially measured and then at 20-day intervals. Blood samples were collected for hematology and serum biochemistry on day 61. Results showed significant (p < 0.05) polycythemia, neutrophilia, thrombocytosis, hepatic and renal derangement in rats exposed to DDVP. Also, albumin, AST, ALP, creatinine, blood urea nitrogen, bilirubin levels and dyslipidemia significantly increased. Cholinergic signs and stunted growth were observed in higher concentrations. Study emphasized hazards of DDVP mishandling and risks of non-compliance with PPE use by workers in-contact with DDVP, as well as misuse/abuse in animals.

敌敌畏是尼日利亚常用的农药，涉及敌敌畏生产、包装或使用设施的人员很少使用个人防护装备来限制农药接触。该研究的目的是通过监测 Wistar 大鼠的血液学和生化变化来确定长期接触敌敌畏的影响。雄性大鼠（n = 60；150−180 g）通过吸入途径暴露于分级浓度的 DDVP（0%、20%、40%、60%、80% 和 100%）60 天。最初测量体重，然后每隔 20 天测量一次体重。第 61 天收集血样进行血液学和血清生化检查。结果显示，暴露于 DDVP 的大鼠出现显着的（p < 0.05）红细胞增多症、中性粒细胞增多症、血小板增多症、肝肾紊乱。此外，白蛋白、AST、ALP、肌酐、血尿素氮、胆红素水平和血脂异常显着升高。在较高浓度下观察到胆碱能症状和生长迟缓。研究强调了敌敌畏处理不当的危害、接触敌敌畏的工人不遵守个人防护装备使用的风险，以及动物误用/滥用的风险。