The COVID-19 pandemic placed public health measures against infectious diseases at the core of global health challenges, especially in cities where more than half of the global population lives. SARS-CoV-2 is an exposure agent recently added to the network of exposures that comprise the human exposome, i.e. the totality of all environmental exposures throughout one’s lifetime. At the same time, the application of measures to tackle SARS-CoV-2 transmission leads to changes in the exposome components and in characteristics of urban environments that define the urban exposome, a complementary concept to the human exposome, which focuses on monitoring urban health. This work highlights the use of a comprehensive systems-based approach of the exposome for better capturing the population-wide and individual-level variability in SARS-CoV-2 spread and its associated urban and individual exposures towards improved guidance and response. Population characteristics, the built environment and spatiotemporal features of city infrastructure, as well as individual characteristics/parameters, socioeconomic status, occupation and biological susceptibility need to be simultaneously considered when deploying non-pharmacological public health measures. Integrating individual and population characteristics, as well as urban-specific parameters is the prerequisite in urban exposome studies. Applications of the exposome approach in cities/towns could facilitate assessment of health disparities and better identification of vulnerable populations, as framed by multiple environmental, urban design and planning co-exposures. Exposome-based applications in epidemics control and response include the implementation of exposomic tools that have been quite mature in non-communicable disease research, ranging from biomonitoring and surveillance to sensors and modeling. Therefore, the exposome can be a novel tool in risk assessment and management during epidemics and other major public health events. This is a unique opportunity for the research community to exploit the exposome concept and its tools in upgrading and further developing site-specific public health measures in cities.

COVID-19 大流行将针对传染病的公共卫生措施置于全球健康挑战的核心，尤其是在全球一半以上人口居住的城市。SARS-CoV-2 是一种最近添加到暴露网络中的暴露剂，该暴露网络构成了人类暴露体，即人一生中所有环境暴露的总和。同时，应对 SARS-CoV-2 传播的措施的应用导致暴露组成分和定义城市暴露组的城市环境特征发生变化，城市暴露组是人类暴露组的补充概念，重点是监测城市健康. 这项工作强调了使用基于系统的综合暴露方法，以更好地捕捉 SARS-CoV-2 传播的人群范围和个体水平的变异性及其相关的城市和个体暴露，以改进指导和响应。在部署非药物公共卫生措施时，需要同时考虑人口特征、城市基础设施的建成环境和时空特征，以及个体特征/参数、社会经济地位、职业和生物敏感性。整合个体和人口特征以及城市特定参数是城市暴露研究的先决条件。在多个环境、城市设计和规划共同暴露框架下，暴露组方法在城市/城镇中的应用有助于评估健康差异并更好地识别弱势群体。基于暴露组的流行病控制和响应应用包括实施在非传染性疾病研究中已经相当成熟的暴露组工具，范围从生物监测和监测到传感器和建模。因此，暴露组可以成为流行病和其他重大公共卫生事件期间风险评估和管理的新工具。对于研究界来说，这是一个独特的机会，可以利用暴露概念及其工具来升级和进一步开发城市中特定地点的公共卫生措施。城市设计和规划共同曝光。基于暴露组的流行病控制和响应应用包括实施在非传染性疾病研究中已经相当成熟的暴露组工具，范围从生物监测和监测到传感器和建模。因此，暴露组可以成为流行病和其他重大公共卫生事件期间风险评估和管理的新工具。对于研究界来说，这是一个独特的机会，可以利用暴露概念及其工具来升级和进一步开发城市中特定地点的公共卫生措施。城市设计和规划共同曝光。基于暴露组的流行病控制和响应应用包括实施在非传染性疾病研究中已经相当成熟的暴露组工具，范围从生物监测和监测到传感器和建模。因此，暴露组可以成为流行病和其他重大公共卫生事件期间风险评估和管理的新工具。对于研究界来说，这是一个独特的机会，可以利用暴露概念及其工具来升级和进一步开发城市中特定地点的公共卫生措施。从生物监测和监视到传感器和建模。因此，暴露组可以成为流行病和其他重大公共卫生事件期间风险评估和管理的新工具。对于研究界来说，这是一个独特的机会，可以利用暴露概念及其工具来升级和进一步开发城市中特定地点的公共卫生措施。从生物监测和监视到传感器和建模。因此，暴露组可以成为流行病和其他重大公共卫生事件期间风险评估和管理的新工具。对于研究界来说，这是一个独特的机会，可以利用暴露概念及其工具来升级和进一步开发城市中特定地点的公共卫生措施。