OBJECTIVE The aim of the current study was to attempt to replicate the finding that the individual alpha frequency (IAF) as well as the absolute difference between IAF and 10 Hz stimulation frequency (IAF-prox) is related to treatment outcome. METHODS Correlations were performed to investigate the relationship between IAF-prox and percentage symptom improvement in a sample of 153 patients with major depressive disorder treated with 10 Hz (N = 59) to the left dorsolateral prefrontal cortex (DLPFC) or 1 Hz (N = 94) to the right DLPFC repetitive Transcranial Magnetic Stimulation (rTMS). RESULTS There was a significant negative correlation between IAF-prox and the percentage of symptom improvement only for the 10 Hz group. Curve fitting models revealed that there was a quadratic association between IAF and treatment response in the 10 Hz group, with a peak at 10 Hz IAF. CONCLUSION The main result of Corlier and colleagues was replicated, and the findings suggest that the distance between 10 Hz stimulation frequency and the IAF may influence clinical outcome in a non-linear manner. SIGNIFICANCE rTMS is often administered at a frequency of 10 Hz, which is the center of the EEG alpha frequency band. The results can make a significant contribution to optimizing the clinical application of rTMS.

中文翻译：

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与重复经颅磁刺激结果相关的个体 alpha 频率接近度：来自 ICON-DB 联盟的独立复制研究

目的 本研究的目的是试图复制个体 α 频率 (IAF) 以及 IAF 和 10 Hz 刺激频率 (IAF-prox) 之间的绝对差异与治疗结果相关的发现。方法 在 153 名重度抑郁症患者样本中进行相关性研究，以研究 IAF-prox 与用 10 Hz (N = 59) 左背外侧前额叶皮层 (DLPFC) 或 1 Hz (N = 94) 到右侧 DLPFC 重复经颅磁刺激 (rTMS)。结果 IAF-prox 与仅 10 Hz 组的症状改善百分比之间存在显着负相关。曲线拟合模型显示，在 10 Hz 组中 IAF 与治疗反应之间存在二次关联，峰值为 10 Hz IAF。结论 重复了 Corlier 及其同事的主要结果，研究结果表明 10 Hz 刺激频率与 IAF 之间的距离可能以非线性方式影响临床结果。意义 rTMS 通常以 10 Hz 的频率进行管理，这是 EEG alpha 频带的中心。结果可以为优化 rTMS 的临床应用做出重大贡献。