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Radiation-induced damage in the lower gastrointestinal tract: Clinical presentation, diagnostic tests and treatment options
Best Practice & Research Clinical Gastroenterology ( IF 3.2 ) Pub Date : 2020-11-10 , DOI: 10.1016/j.bpg.2020.101707
Isis K. Araujo , Diego Muñoz-Guglielmetti , Meritxell Mollà

Radiation therapy is an important ally when treating malignant lesions in the pelvic area, but it is not exempt of adverse events. There are some measures that can be taken to reduce the possibility of these effects, but some are non-modifiable factors related to previous treatments, location of the lesions or comorbidities. There is a wide variety of clinical presentations that can be of an acute or chronic onset that go from mild to severe forms or that can have a great impact in the quality of life. Medical available therapies as metronidazole, sucralfate, mesalizine or probiotics, can be of aid although some lack of solid evidence of efficacy. Endoscopic treatment can be performed with argon plasma coagulation, bipolar cautery, radiofrequency, laser therapy or dilation. Hyperbaric therapy can be applied in refractory cases and surgery must be reserved to selected patients due to its high morbidity and mortality.



中文翻译:

辐射引起的下胃肠道损害:临床表现,诊断检查和治疗选择

放射疗法是治疗骨盆区域恶性病变的重要盟友,但不能排除不良事件。可以采取一些措施来减少这些影响的可能性,但是有些是与以前的治疗方法,病变位置或合并症相关的不可改变的因素。有各种各样的临床表现,可能是轻度到重度的急性或慢性发作,或对生活质量产生重大影响。尽管缺乏确凿的疗效证据,但仍可使用甲硝唑,硫糖铝,美沙利嗪或益生菌等医学疗法。内窥镜治疗可以通过氩等离子体凝结,双极电灼,射频,激光治疗或扩张来进行。

更新日期:2020-12-13
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