A zinc bromide-catalyzed synthesis of 5-substituted tetrazoles via DNA-conjugated nitriles using sodium azide has been developed. The protocol offered moderate to excellent yields of tetrazoles with a broad range of substrates, including a variety of functionalized aromatic, heterocyclic, and aliphatic nitriles. In addition, the electronic effect within the substrate scope was evaluated. DNA fidelity was assessed by ligation efficiency and amplifiability analysis. The ability to generate tetrazoles expands the diversity of heterocycles in the preparation of DNA-encoded chemical libraries.

中文翻译：

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DNA共轭腈合成5-取代四唑

已经开发了使用叠氮化钠通过DNA 共轭腈合成 5-取代四唑的溴化锌。该协议提供了中等至优异的四唑产量，具有广泛的底物，包括各种功能化的芳族、杂环和脂肪族腈。此外，评价了基板范围内的电子效应。DNA保真度通过连接效率和扩增性分析进行评估。在制备 DNA 编码的化学文库时，产生四唑的能力扩大了杂环的多样性。