Mussel-inspired capsules toward reaction-triggered cargo release,Materials Chemistry Frontiers

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Mussel-inspired capsules toward reaction-triggered cargo release
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2020-10-21 , DOI: 10.1039/d0qm00604a
Yiying Sun _{1,

2,

3,

4,

5} , Jiafu Shi _{3,

4,

5,

6,

7} , Ziyi Cai _{1,

2,

3,

4,

5} , Yizhou Wu _{1,

2,

3,

4,

5} , Weiran Li _{3,

4,

5,

6,

7} , Qian Huo _{1,

2,

3,

4,

5} , Zhongyi Jiang _{1,

2,

3,

4,

5}

Affiliation

Exploring systems with distinct stimuli-response properties is vital for controlled release. In our study, a reaction-triggered system based on enzyme-encased capsules is constructed through mussel-inspired chemistry for controlled release of insulin (INS, a kind of protein hormone for diabetes mellitus treatment). In detail, glucose oxidase (GOD) and INS were first entrapped in CaCO₃ particles through a co-precipitation method. Tannic acid (TA, a natural polyphenol) was adhered on the particle surface and conjugated with polyethyleneimine (PEI) through a Schiff base reaction and electrostatic interactions, thus acquiring TA–PEI (TP) capsules encasing GOD and INS. The GOD inside the capsules catalysed the oxidation of glucose to form gluconic acid, which caused the enrichment of protons (H⁺) around the capsules. The decrease of the pH value further broke the C [double bond, length as m-dash]

N bond in the capsule wall, which led to the disassembly of the capsules and the release of INS. The capsular system could continuously release 73.1% of the INS in 3 h, and exhibited a specific response to glucose. Combined with the facile and mild preparation of the enzyme-encased capsules, it was expected that the as-constructed capsular system could be applied for the delivery and controlled release of a broad range of cargoes.

中文翻译：

贻贝启发的胶囊用于反应触发的货物释放

探索具有独特刺激响应特性的系统对于控释至关重要。在我们的研究中，通过以贻贝为灵感的化学物质构建了基于酶包裹的胶囊的反应触发系统，以控制胰岛素的释放（INS，一种治疗糖尿病的蛋白激素）。详细地，首先通过共沉淀法将葡萄糖氧化酶（GOD）和INS包埋在CaCO ₃颗粒中。单宁酸（TA，一种天然多酚）粘附在颗粒表面，并通过席夫碱反应和静电相互作用与聚乙烯亚胺（PEI）结合，从而获得了包裹了GOD和INS的TA-PEI（TP）胶囊。胶囊中的GOD催化葡萄糖氧化形成葡萄糖酸，从而引起质子的富集（H ⁺）在胶囊周围。pH值的降低进一步破坏了 [双键，长度为m-破折号]