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High UV-Vis-NIR Light-Induced Antibacterial Activity by Heterostructured TiO2-FeS2 Nanocomposites
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2020-11-12 , DOI: 10.2147/ijn.s282689 Chinmaya Mutalik , Yu-Cheng Hsiao , Yi-Hsuan Chang , Dyah Ika Krisnawati , Moh Alimansur , Achmad Jazidie , Mohammad Nuh , Chia-Che Chang , Di-Yan Wang , Tsung-Rong Kuo
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2020-11-12 , DOI: 10.2147/ijn.s282689 Chinmaya Mutalik , Yu-Cheng Hsiao , Yi-Hsuan Chang , Dyah Ika Krisnawati , Moh Alimansur , Achmad Jazidie , Mohammad Nuh , Chia-Che Chang , Di-Yan Wang , Tsung-Rong Kuo
Purpose: Antibiotic resistance issues associated with microbial pathogenesis are considered to be one of the most serious current threats to health. Fortunately, TiO2, a photoactive semiconductor, was proven to have antibacterial activity and is being widely utilized. However, its use is limited to the short range of absorption wavelength.
Methods: In this work, heterostructured TiO2-FeS2 nanocomposites (NCs) were successfully prepared by a facile solution approach to enhance light-induced antibacterial activity over a broader absorption range.
Results: In TiO2-FeS2 NCs, FeS2 NPs, as light harvesters, can effectively increase light absorption from the visible (Vis) to near-infrared (NIR). Results of light-induced antibacterial activities indicated that TiO2-FeS2 NCs had better antibacterial activity than that of only TiO2 nanoparticles (NPs) or only FeS2 NPs. Reactive oxygen species (ROS) measurements also showed that TiO2-FeS2 NCs produced the highest relative ROS levels. Unlike TiO2 NPs, TiO2-FeS2 NCs, under light irradiation with a 515-nm filter, could absorb light wavelengths longer than 515 nm to generate ROS. In the mechanistic study, we found that TiO2 NPs in TiO2-FeS2 NCs could absorb ultraviolet (UV) light to generate photoinduced electrons and holes for ROS generation, including ⋅O2− and ⋅OH; FeS2 NPs efficiently harvested Vis to NIR light to generate photoinduced electrons, which then were transferred to TiO2 NPs to facilitate ROS generation.
Conclusion: TiO2-FeS2 NCs with superior light-induced antibacterial activity could be a promising antibacterial agent against bacterial infections.
Keywords: antibacterial agent, antibacterial mechanism, reactive oxygen species, light harvester, light-induced antibacterial activity
中文翻译：
异质结构 TiO2-FeS2 纳米复合材料具有高紫外-可见-近红外光诱导抗菌活性
目的：与微生物发病机制相关的抗生素耐药性问题被认为是当前对健康最严重的威胁之一。幸运的是，TiO 2是一种光敏半导体，已被证明具有抗菌活性并得到广泛应用。然而，它的使用仅限于短范围的吸收波长。
方法：在这项工作中，通过简单的溶液方法成功制备了异质结构TiO 2 -FeS 2纳米复合材料（NC），以在更广泛的吸收范围内增强光诱导的抗菌活性。
结果：在TiO 2 -FeS 2 NCs中，FeS 2 NPs作为光收集器，可以有效增加从可见光（Vis）到近红外（NIR）的光吸收。光诱导抗菌活性的结果表明，TiO 2 -FeS 2 NCs比仅TiO 2纳米粒子(NPs)或仅FeS 2 NPs具有更好的抗菌活性。活性氧（ROS）测量还表明TiO 2 -FeS 2 NCs产生最高的相对ROS水平。与TiO 2 NPs不同，TiO 2 -FeS 2 NCs在515 nm滤光片的光照射下，可以吸收大于515 nm的光波长以产生ROS。在机理研究中，我们发现TiO 2 -FeS 2 NCs中的TiO 2 NPs可以吸收紫外（UV）光，产生光生电子和空穴，从而产生ROS，包括⋅O 2 −和⋅OH； FeS 2 NPs有效地收集可见光到近红外光以产生光生电子，然后将其转移到TiO 2 NPs以促进ROS的产生。
结论： TiO 2 -FeS 2 NCs 具有优异的光诱导抗菌活性，可能是一种有前景的抗细菌感染抗菌剂。
关键词:抗菌剂, 抗菌机制, 活性氧, 光捕获器, 光诱导抗菌活性
更新日期：2020-11-12
Methods: In this work, heterostructured TiO2-FeS2 nanocomposites (NCs) were successfully prepared by a facile solution approach to enhance light-induced antibacterial activity over a broader absorption range.
Results: In TiO2-FeS2 NCs, FeS2 NPs, as light harvesters, can effectively increase light absorption from the visible (Vis) to near-infrared (NIR). Results of light-induced antibacterial activities indicated that TiO2-FeS2 NCs had better antibacterial activity than that of only TiO2 nanoparticles (NPs) or only FeS2 NPs. Reactive oxygen species (ROS) measurements also showed that TiO2-FeS2 NCs produced the highest relative ROS levels. Unlike TiO2 NPs, TiO2-FeS2 NCs, under light irradiation with a 515-nm filter, could absorb light wavelengths longer than 515 nm to generate ROS. In the mechanistic study, we found that TiO2 NPs in TiO2-FeS2 NCs could absorb ultraviolet (UV) light to generate photoinduced electrons and holes for ROS generation, including ⋅O2− and ⋅OH; FeS2 NPs efficiently harvested Vis to NIR light to generate photoinduced electrons, which then were transferred to TiO2 NPs to facilitate ROS generation.
Conclusion: TiO2-FeS2 NCs with superior light-induced antibacterial activity could be a promising antibacterial agent against bacterial infections.
Keywords: antibacterial agent, antibacterial mechanism, reactive oxygen species, light harvester, light-induced antibacterial activity
中文翻译：
异质结构 TiO2-FeS2 纳米复合材料具有高紫外-可见-近红外光诱导抗菌活性
目的：与微生物发病机制相关的抗生素耐药性问题被认为是当前对健康最严重的威胁之一。幸运的是，TiO 2是一种光敏半导体，已被证明具有抗菌活性并得到广泛应用。然而，它的使用仅限于短范围的吸收波长。
方法：在这项工作中，通过简单的溶液方法成功制备了异质结构TiO 2 -FeS 2纳米复合材料（NC），以在更广泛的吸收范围内增强光诱导的抗菌活性。
结果：在TiO 2 -FeS 2 NCs中，FeS 2 NPs作为光收集器，可以有效增加从可见光（Vis）到近红外（NIR）的光吸收。光诱导抗菌活性的结果表明，TiO 2 -FeS 2 NCs比仅TiO 2纳米粒子(NPs)或仅FeS 2 NPs具有更好的抗菌活性。活性氧（ROS）测量还表明TiO 2 -FeS 2 NCs产生最高的相对ROS水平。与TiO 2 NPs不同，TiO 2 -FeS 2 NCs在515 nm滤光片的光照射下，可以吸收大于515 nm的光波长以产生ROS。在机理研究中，我们发现TiO 2 -FeS 2 NCs中的TiO 2 NPs可以吸收紫外（UV）光，产生光生电子和空穴，从而产生ROS，包括⋅O 2 −和⋅OH； FeS 2 NPs有效地收集可见光到近红外光以产生光生电子，然后将其转移到TiO 2 NPs以促进ROS的产生。
结论： TiO 2 -FeS 2 NCs 具有优异的光诱导抗菌活性，可能是一种有前景的抗细菌感染抗菌剂。
关键词:抗菌剂, 抗菌机制, 活性氧, 光捕获器, 光诱导抗菌活性
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