Amino acid modification plays an important role across several fields, including synthetic organic chemistry, materials science, targeted drug delivery and the probing of biological function. Although a myriad of methods now exist for the modification of peptides or proteins, many of these target a handful of the most reactive proteinogenic amino acids. Photocatalysis has recently emerged as a mild approach for amino acid modification, generating a sizable toolbox of reactions capable of modifying almost all of the canonical amino acids. These reactions are characterised by their mild, physiologically compatible conditions, greatly enhancing their usefulness for amino acid modification. This review aims to introduce the field of photocatalytic amino acid modification and discusses the most recent advances.

中文翻译：

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氨基酸修饰的光催化方法

氨基酸修饰在多个领域中发挥着重要作用，包括合成有机化学，材料科学，靶向药物递送和生物学功能的探测。尽管现在存在用于修饰肽或蛋白质的多种方法，但是许多方法都靶向少数最具活性的蛋白原氨基酸。最近，光催化已成为一种温和的氨基酸修饰方法，可产生可修饰几乎所有标准氨基酸的可观反应工具箱。这些反应的特征在于它们温和的，生理上相容的条件，大大增强了它们在氨基酸修饰中的用途。这篇综述旨在介绍光催化氨基酸修饰的领域并讨论最新进展。