The progress in corneal translational medicine,Biomaterials Science

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The progress in corneal translational medicine
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-11-11 , DOI: 10.1039/d0bm01209b
Zoe Hancox _{1,

2,

3,

4,

5} , Saeed Heidari Keshel _{6,

7,

8,

9,

10} , Safiyya Yousaf _{1,

2,

3,

4,

5} , Morvarid Saeinasab _{10,

11,

12,

13,

14} , Mohammad-Ali Shahbazi _{15,

16,

17,

18,

19} , Farshid Sefat _{1,

2,

3,

4,

5}

Affiliation

Department of Biomedical and Electronics Engineering
School of Engineering
University of Bradford
Bradford
UK
Department of Tissue Engineering and Applied Cell Sciences
School of Advanced Technologies in Medicine
Shahid Beheshti University of Medical Sciences
Tehran
Iran
Department of Biology
Faculty of Science
Ferdowsi University of Mashhad
Mashhad
Drug Research Program
Division of Pharmaceutical Chemistry and Technology
Faculty of Pharmacy
FI-00014 University of Helsinki
Helsinki

Cornea tissue is in high demand by tissue donation centres globally, and thus tissue engineering cornea, which is the main topic of corneal translational medicine, can serve as a limitless alternative to a donated human cornea tissue. Tissue engineering aims to produce solutions to the challenges associated with conventional cornea tissue, including transplantation and use of human amniotic membrane (HAM), which have issues with storage and immune rejection in patients. Accordingly, by carefully selecting biomaterials and fabrication methods to produce these therapeutic tissues, the demand for cornea tissue can be met, with an improved healing outcome for recipients with less associated harmful risks. In this review paper, we aim to present the recent advancements in the research and clinical applications of cornea tissue, applications including biomaterial selection, fabrication methods, scaffold structure, cellular response to these scaffolds, and future advancements of these techniques.

中文翻译：

角膜转化医学的进展

全球组织捐赠中心对角膜组织的需求很高，因此作为角膜转化医学的主要课题的组织工程角膜可以作为捐赠的人类角膜组织的无限替代品。组织工程旨在为解决与常规角膜组织相关的挑战提供解决方案，包括移植和使用人类羊膜（HAM），这些问题与患者的储存和免疫排斥有关。因此，通过仔细选择生物材料和制造方法来生产这些治疗性组织，可以满足对角膜组织的需求，对于具有较少相关有害风险的接受者具有改善的愈合结果。在这篇评论文章中，我们旨在介绍角膜组织研究和临床应用的最新进展，

更新日期：2020-11-12

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