A monocyclic ring in their structure characterizes monobactams, a subclass of β-lactam antibiotics. Many of these compounds have a bactericidal mechanism of action and acts as penicillin and cephalosporins, interfering with bacterial cell wall biosynthesis. The synthesis of novel β-lactams is an emerging area of organic synthesis research due to the problem of increasing bacterial resistance to existing β -lactam antibiotics, and, in this way, new compounds have been presented with several structural modifications, aiming to improve biological activities. Among the biological activities studied, the most outstanding are antibacterial, antitubercular, anticholesterolemic, anticancer, antiinflammatory, antiviral, and anti-enzymatic, among others. This review explores the vast number of works related to monocyclic β-lactams, compounds of great importance in scientific research.

单环的结构表征了单bactams（β-内酰胺抗生素的一个亚类）。这些化合物中的许多具有杀菌作用机理，并起着青霉素和头孢菌素的作用，干扰细菌细胞壁的生物合成。由于细菌对现有β-内酰胺类抗生素的耐药性增加，新型β-内酰胺类化合物的合成是有机合成研究的一个新兴领域，以此方式，已提出了一些具有某些结构修饰的新化合物，旨在改善生物学特性。活动。在研究的生物活性中，最杰出的是抗菌，抗结核，抗胆固醇，抗癌，抗炎，抗病毒和抗酶活性等。这篇评论探索了与单环β-内酰胺有关的大量作品，