Tandem Reaction of Tertiary Enamides as a Synthetic Strategy to Construct the Fused N-Pentacyclic Skeleton of Erythrina Alkaloid Derivatives,Organic Letters

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Tandem Reaction of Tertiary Enamides as a Synthetic Strategy to Construct the Fused N-Pentacyclic Skeleton of Erythrina Alkaloid Derivatives
Organic Letters ( IF 4.9 ) Pub Date : 2020-11-11 , DOI: 10.1021/acs.orglett.0c03162
Hanlin Yang ₁ , Wenzhong Li ₁ , Xin-Ming Xu ₁ , Zu-Li Wang ₂

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An exquisite protocol to the synthesis of erythrina-related structural derivatives was developed, which is composed of a nucleophilic addition of tertiary enamides to ketonic carbonyls and the trapping of acyliminium by an aromatic unit. This protocol afforded a powerful method for the construction of diverse fused N-pentacyclic skeletons in high efficiency and excellent diastereoselectivity by just using different acid catalysts.

中文翻译：

叔酰胺串联反应作为合成策略的Erythrina生物碱衍生物的融合N-五环骨架。

开发了一种合成赤藓素相关结构衍生物的精妙方案，该方案由叔酰胺与酮羰基的亲核加成以及芳香族单元对酰基亚胺的捕获组成。该方案为仅使用不同的酸催化剂就能高效，优异的非对映选择性提供了一个强大的方法，可用于构建各种稠合的N-五环骨架。

更新日期：2020-11-21

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