Palladium/Copper Cocatalyzed C–H Activation and C–C Bond Regioselective Cleavage Reaction for the Synthesis of Fused Chromeno Quinolines,Organic Letters

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Palladium/Copper Cocatalyzed C–H Activation and C–C Bond Regioselective Cleavage Reaction for the Synthesis of Fused Chromeno Quinolines
Organic Letters ( IF 4.9 ) Pub Date : 2020-11-10 , DOI: 10.1021/acs.orglett.0c03229
Guodong Shen ₁ , Zeyou Wang ₁ , Xianqiang Huang ₁ , Min Hong ₁ , Shuhua Fan ₁ , Xin Lv ₂

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A method for the synthesis of fused chromeno quinolines by the palladium/copper cocatalyzed C–H bond activation and C–C bond cleavage reaction has been developed. A variety of fused chromeno quinoline derivatives could be synthesized by coumarin derivatives and anilines through the C–C bond cleavage/C–H functionalization/C–C bond formation process. The MTT assay was used to evaluate the chromeno quinolines against the human cervix tumor cells (HeLa), 3c and 9c without coordination metals showed good inhibition effect.

中文翻译：

钯/铜共催化C–H活化和C–C键区域选择性裂解反应合成熔融的Chromeno喹啉

已经开发了一种通过钯/铜共催化的C–H键活化和C–C键裂解反应合成稠合的chromeno喹啉的方法。香豆素衍生物和苯胺可以通过C–C键裂解/ C–H功能化/ C–C键形成过程来合成各种稠合的chromeno喹啉衍生物。采用MTT法评价了铬诺喹啉对人宫颈肿瘤细胞（HeLa），3c和9c的抑制作用，而没有配位金属表现出良好的抑制作用。

更新日期：2020-11-21

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