Self-Assembled Bio-Organometallic Nanocatalysts for Highly Enantioselective Direct Aldol Reactions,Langmuir

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Self-Assembled Bio-Organometallic Nanocatalysts for Highly Enantioselective Direct Aldol Reactions
Langmuir ( IF 3.7 ) Pub Date : 2020-11-11 , DOI: 10.1021/acs.langmuir.0c01485
Xuejiao Yang ₁ , Liwei Zhang ₁ , Yaoyu Liang ₁ , Yuefei Wang _{1,

2} , Yuhe Shen ₁ , Qiguo Xing ₁ , Wei Qi _{1,

2,

3} , Pengfei Wang ₄ , Xiao Liu ₁ , Mengyao Yang ₁ , Rongxin Su _{1,

2,

3} , Mingxia He ₄ , Zhimin He ₁

Affiliation

Supramolecular nanocatalysts were designed for asymmetric reactions through the self-assembly process of a bio-organometallic molecule, ferrocene-l-prolinamide (Fc-CO-NH-P). Fc-CO-NH-P could self-assemble into versatile nanostructures in water, including nanospheres, nanosheets, nanoflowers, and pieces. In particular, the self-assembled nanoflowers exhibited a superior specific surface area, high stability, and delicate three-dimensional (3D) chiral catalytic active sites. The nanoflowers could serve as heterogeneous catalysts with an excellent catalytic performance toward direct aldol reactions in aqueous solution, achieving both high yield (>99%) and stereoselectivity (anti/syn = 97:3, ee% >99%). This study proposed a significant strategy to fabricate supramolecular chiral catalysts, serving as a favorable template for designing new asymmetric catalysts.

中文翻译：

自组装的生物有机金属纳米催化剂的高度对映选择性直接羟醛反应。

超分子纳米催化剂被设计用于通过生物有机金属分子的自组装过程，二茂铁-不对称反应升-脯氨酰胺（Fc-CO-NH-P）。Fc-CO-NH-P可以在水中自组装成通用的纳米结构，包括纳米球，纳米片，纳米花和碎片。特别地，自组装的纳米花表现出优异的比表面积，高稳定性和精细的三维（3D）手性催化活性位点。纳米花可以用作非均相催化剂，对水溶液中的直接羟醛反应具有优异的催化性能，既可实现高收率（> 99％）又可实现立体选择性（反/ syn = 97：3，ee％> 99％）。这项研究提出了一种重要的策略来制备超分子手性催化剂，作为设计新型不对称催化剂的有利模板。

更新日期：2020-11-25

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