A new electrochemical sensor has been constructed based on the in situ preparation of gold nanoparticle embedded on reduced graphene oxide and polypyrrole nanotube (AuNP@rGO/PPyNT) composite through a nanosecond laser-induced heating technique. The as-prepared composite is used for individual as well as the simultaneous electrochemical determination of chemotherapy drug (furazolidone, FU) and anticancer drug (flutamide, FLT). The composite was analyzed by X-ray Diffraction, scanning electron microscopy/energy-dispersive X-ray analysis, transmission electron microscopy, Raman spectrometry, and X-ray photoelectron spectroscopy analysis, thus confirming the successful synthesis of this composite and its physical features. The modified AuNP@rGO/PPyNT electrode was examined through cyclic voltammetry and differential pulse voltammetry (DPV) methods in pH 7.0 for the determination of FU and FLT in individual, simultaneous, and mixed systems. The fabricated sensor showed wide linear responses (0.01–1080.11 μM and 0.01–1214.11 μM) of analytes, with the lower limits of detection of 2.3 and 2.45 nM and higher sensitivity of 53.75 and 50.06 μA μM^–1 cm^–2, respectively. Furthermore, the constructed sensor demonstrates higher stability, reproducibility, and repeatability, and is effectively applied for the analysis of FU and FLT content in the human serum sample analysis with satisfactory recovery.

中文翻译：

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纳米金嵌入还原的氧化石墨烯/聚吡咯纳米复合材料中：呋喃唑酮和氟他胺的伏安法传感

基于原位构建了新的电化学传感器纳秒激光诱导加热技术制备嵌入还原型氧化石墨烯和聚吡咯纳米管（AuNP @ rGO / PPyNT）复合材料的金纳米粒子。所制备的复合物可用于化学药物（呋喃唑酮，FU）和抗癌药物（氟他米特，FLT）的单独以及同时电化学测定。通过X射线衍射，扫描电子显微镜/能量分散X射线分析，透射电子显微镜，拉曼光谱和X射线光电子能谱分析对复合材料进行分析，从而证实了该复合材料的成功合成及其物理特征。通过循环伏安法和差分脉冲伏安法（DPV）在pH 7.0下对修饰的AuNP @ rGO / PPyNT电极进行了检测，以测定单个，同时，和混合系统。制成的传感器显示出较宽的线性响应（0.01–1080.11μM和0.01–1214.11μM），检测下限为2.3和2.45 nM，灵敏度更高，为53.75和50.06μAμM分别为^–1厘米^–2。此外，所构建的传感器显示出更高的稳定性，可重复性和可重复性，并有效地用于人体血清样品分析中FU和FLT含量的分析，回收率令人满意。