Mild and Selective Method of Bromination of Flavonoids,Journal of Natural Products

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Mild and Selective Method of Bromination of Flavonoids
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-11-10 , DOI: 10.1021/acs.jnatprod.0c00655
Martina Hurtová _{1,

2} , David Biedermann ₁ , Marek Kuzma ₁ , Vladimír Křen ₁

Affiliation

A new method was developed for the mild and selective bromination of simple aromatic compounds and flavonoids in good yields using α,β-dibromohydrocinnamic acid in the presence of a base. This procedure enables selective mono- or dibromination of compounds highly sensitive to oxidative or radical attack. New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. These brominated derivatives can be used as valuable synthetic intermediates in further synthesis.

中文翻译：

黄酮类化合物的温和选择性溴化方法

开发了一种在碱存在下使用 α,β-二溴氢化肉桂酸以良好收率温和选择性溴化简单芳香族化合物和黄酮类化合物的新方法。该程序能够对氧化或自由基攻击高度敏感的化合物进行选择性单溴化或二溴化。制备了水飞蓟素黄酮木脂素和相关黄酮类化合物的新型溴化衍生物。这些溴化衍生物可在进一步合成中用作有价值的合成中间体。

更新日期：2020-11-25

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