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Chiral Resolution of Mandelic Acid through Preferential Cocrystallization with Nefiracetam
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2020-11-09 , DOI: 10.1021/acs.cgd.0c01236 Xavier Buol 1 , Camila Caro Garrido 1 , Koen Robeyns 1 , Nikolay Tumanov 2 , Laurent Collard 1 , Johan Wouters 2 , Tom Leyssens 1
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2020-11-09 , DOI: 10.1021/acs.cgd.0c01236 Xavier Buol 1 , Camila Caro Garrido 1 , Koen Robeyns 1 , Nikolay Tumanov 2 , Laurent Collard 1 , Johan Wouters 2 , Tom Leyssens 1
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In this paper, we identified a cocrystal conglomerate of mandelic acid using a drug compound as a coformer. We then developed a chiral resolution process based on preferential cocrystallization. Several versions of such a process were explored and optimized, leading to a successful resolution of mandelic acid, evidencing the efficiency of our system. Excellent enantiopurity (98–99%) was obtained with a process that can run for multiple cycles.
中文翻译：
通过与奈非西坦的优先共结晶手性拆分扁桃酸
在本文中，我们确定了使用药物化合物作为共形成剂的扁桃酸共结晶聚集体。然后，我们开发了基于优先共结晶的手性拆分方法。探索和优化了此过程的多个版本，从而成功分离出扁桃酸，证明了我们系统的效率。可以进行多个循环的过程获得了优异的对映体纯度（98–99％）。
更新日期：2020-12-02
中文翻译：
通过与奈非西坦的优先共结晶手性拆分扁桃酸
在本文中，我们确定了使用药物化合物作为共形成剂的扁桃酸共结晶聚集体。然后，我们开发了基于优先共结晶的手性拆分方法。探索和优化了此过程的多个版本，从而成功分离出扁桃酸，证明了我们系统的效率。可以进行多个循环的过程获得了优异的对映体纯度（98–99％）。
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