The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19.

中文翻译：

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临床 HDAC 抑制剂是防止 SARS-CoV2 进入的有效药物

到 2019 年底，COVID-19 的爆发对人类健康构成了严重威胁，并危及全球经济。然而，目前没有有效的药物可以治疗 COVID-19，对抗它的需求很大。在这里，我们结合计算筛选和有效的细胞假型病毒系统，证实临床 HDAC 抑制剂可以有效预防 SARS-CoV-2，并有可能用于对抗 COVID-19。